Antibacterial sulfone and sulfoxide substituted heterocyclic urea compounds

1. A compound of the Formula (I):

in which:

R 1 is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl;

X is selected from the group consisting of C and N atom;

Y is selected from the group consisting of SO and SO 2 ;

R 2 is selected from the group consisting of substituted or unsubstituted alcohol, substituted or unsubstituted O-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, and perfluoroalkyl; and

R 3 is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R 3 is null when X is N.

2. The compound of claim 1 , wherein R 1 is a substituted or unsubstituted phenyl or thiophene group.

3. The compound of claim 2 , wherein R 1 is a phenyl group having one or more substituents selected from the group consisting of halogen, cyano, (C 1 - 6 )alkyl, mono to perfluoro(C 1 - 3 )alkyl, (C 3 - 7 )cycloalkyl, (C 2 - 6 )alkenyl, (C 1 - 6 )alkoxy, (C 2 - 6 )alkenoxy, hydroxy, amino, mono- or di-(C 1 - 6 )alkylamino, acylamino, nitro, carboxy, (C 1 - 6 )alkoxycarbonyl, (C 1 - 6 )alkenyloxycarbonyl, (C 1 - 6 )alkoxycarbonyl(C 1 - 6 )alkyl, carboxy(C 1 - 6 )alkyl, (C 1 - 6 )alkylcarbonyloxy, carboxy(C 1 - 6 )alkyloxy, (C 1 - 6 )alkoxycarbonyl(C 1 - 6 )alkoxy, (C 1 - 6 )alkylthio, (C 1 - 6 )alkylsulphinyl, (C 1 - 6 )alkylsulphonyl, sulphamoyl, mono- and di-(C 1 - 6 )-alkylsulphamoyl and carbamoyl.

4. The compound of claim 1 , wherein R 1 is selected from the group consisting of 3-fluorophenyl, 4-fluorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 4-bromophenyl, 3-iodophenyl, 4-iodophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3,4-memethylendioxyphenyl, 3,4-difluorophenyl, 3,4-dichlorophenyl, 3,4-dibromophenyl, 3,4-dimethylphenyl, 3,4-(-CH 2 CH 2 CH 2 -)phenyl, 3,4-(-OCH 2 CH 2 O-)phenyl, 3-chloro-4-fluorophenyl, benzo[1,3]dioxyl-5-yl, and 3-3-cyanophenyl, thiophen-2-yl, thiophen-3-yl, 4,5-di-bromo-thiophen-2yl, 5-chloro-thiophen-2yl, and 5-bromo-thiophen-2yl, 5-fluoro-thiophen-2-yl, and 3,5 difluorophenyl.

5. The compound of claim 1 , wherein Y is an SO group.

6. The compound of claim 5 , wherein X is a C.

7. The compound of claim 5 , wherein X is a N.

8. The compound of claim 1 , wherein Y is an SO 2 group.

9. The compound of claim 8 , wherein X is a C.

10. The compound of claim 8 , wherein X is a N.

11. The compound of claim 1 , wherein R 2 is substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, or perfluoroalkyl group.

12. The compound of claim 11 , wherein R 2 is selected from the group consisting of methyl, ethyl, n-propyl, cyclopropyl, n-butyl, allyl, 4-methylphenyl, 4-methylbenzyl, 4-acetamidophenyl, 4-tert-butylphenyl, 3,4-dimethylphenyl, 4-chlorophenyl, 4-chlorobenzyl, p-tolylmethyl, 4-fluorophenyl, 4-fluorobenzyl, 3-methylbutane-1-yl, 4-methoxyphenyl, 4-methoxybenzyl, 2-phenylethyl, 3,4-dimethoxyphenyl, (4-methoxyphenyl)methyl, 3,5-dimethylisoxazole-4-yl, 2-(pyrazin-2-yl)ethyl, (4-chlorophenyl)methyl, 3,3,3-trifluoropropyl, 2-(methylsulfonyl)ethyl, 3-methylphenyl, thiazole-2-yl, 2-methylpropyl, 2-methoxyethyl, 2,6-dimethylphenyl, 4-trifluoromethoxyphenyl, benzo[1,3]dioxole-5, 2,4-dimethoxyethyl, 2-(pyridin-2-yl)ethyl, 2-hydroxypropyl, 5-(methoxymethyl)-1,3,4-thiadiazole-2-yl, 2-methylbutane-1-yl, 2-methyl-tetrahydro-furan-3-yl, furan-2-ylmethyl, [1,3,4]thiadiazole-2-yl, cyclopentyl, 1-methyl-1H-imidazole-2-yl, pyridine-3-yl, benzo[1,3]dioxole-5-yl, 2-amino-ethyl, 4-methoxy-benzene, 2,4-dimethoxy-phenyl, 4-nitro -benzyl, 4-amino-benzyl, 6-methoxy-pyridine-3-yl, 2-methoxy-pyrimidine-5-yl, 2,2-difluoro -benzo[1,3]dioxole-5-yl, N-trifluoromethyl-4-carbamoyl-phenyl, 5-methoxy-pyrazine-2-yl, 5-oxo-4,5-dihydro-pyrazine-2-yl, 2-oxo-1,2-dihydro-pyrimidine-5-yl, 6-oxo-1,6-dihydro-pyridine -3-yl, pyrimidine-2-yl, 2-methylamino-pyrimidine-5-yl, 2-Dimethylamino-pyrimidine-5-yl, 4-carbamoyl-phenyl, N-methyl-4-carbamoyl-phenyl, 2-Amino-pyrimidine-5-yl, 6-methylamino -pyridine-3-yl, 2-methyl-1H-benzoimidazole-5-yl, and 2-hydroxyethyl.

13. The compound of claim 1 , wherein R 3 is selected from the group consisting of H, methyl, ethyl, 2-hydroxyethyl, 2-hydroxymethyl, 2-methoxyethyl, 2-aminoethyl, propyl, cyclopropyl, isopropyl, 2,4-dimethoxybenzyl, and 2-methanesulfonylaminoethyl.

14. The compound of claim 1 , wherein R 2 -Y together form a group selected from 4-methylbenzene-1-sulfonyl, 4-acetamidobenzene-1-sulfonyl, 4-tert-butylbenzene-1-sulfonyl, 3,4-dimethylbenzene-1-sulfonyl, 4-chlorobenzene-1-sulfonyl, p-tolylmethanesulfonyl, 4-fluorobenzene-1-sulfonyl, 3-methylbutane-1-sulfonyl, propane-1-sulfonyl, 4-methoxybenzene -1-sulfonyl, 2-phenylethanesulfonyl, 3,4-dimethoxybenzene-1-sulfonyl, (4-methoxyphenyl)methanesulfonyl, 3,5-dimethylisoxazole-4-sulfonyl, 2-(pyrazin-2-yl)ethanesulfonyl, 3-methylbenzene-1-sulfonyl, 3,5-dimethylisoxazole-4-sulfonyl, (4-chlorophenyl)methanesulfonyl, cyclopropane-1-sulfonyl, butane-2-sulfonyl, 3,3,3-trifluoropropane-1-sulfonyl, 2-(methylsulfonyl)ethanesulfonyl, ethane-1-sulfonyl, methanesulfonyl, thiazole-2-sulfonyl, 2-methylpropane-1-sulfonyl, 2-methoxyethanesulfonyl, 2,6-dimethylbenzene-1-sulfonyl, 4-trifluoromethoxybenzene-1-sulfonyl, benzo[1,3]dioxole-5-sulfonyl, 2,4-dimethoxyethanesulfonyl, 2-(pyridin-2-yl)ethanesulfonyl, 2-hydroxypropane-1-sulfonyl, prop-2-ene-1-sulfonyl, 5-(methoxymethyl)-1,3,4-thiadiazole-2-sulfonyl, 2-methylbutane-1-sulfonyl, propane-2-sulfonyl, 2-methyl-tetrahydro-furan-3-sulfonyl, furan-2-ylmethanesulfonyl, [1,3,4]thiadiazole-2-sulfonyl, cyclopentanesulfonyl, 1-methyl-1H-imidazole -2-sulfonyl, benzo[1,3]dioxole-5-sulfonyl, 2-amino-ethanesulfonyl, 4-methoxy-benzenesulfonyl, 2,4-dimethoxyphenylsulfonyl, pyridine-3-sulfonyl, 4-nitro-benzenesulfonyl, 4-amino -benzenesulfonyl, 6-methoxy-pyridine-3-sulfonylmethyl, 2-methoxy-pyrimidine-5-sulfonyl, 2,2-difluoro-benzo[1,3]dioxole-5-sulfonyl, N-trifluoromethyl-4-carbamoyl-phenyl-sulfonyl, 5-methoxy-pyrazine-2-sulfonyl, 5-oxo-4,5-dihydro-pyrazine-2-sulfonyl, 2-oxo-1,2-dihydro -pyrimidine-5-sulfonyl, 6-oxo-1,6-dihydro-pyridine-3-sulfonyl, pyrimidine-2-sulfonyl, 2-methylamino-pyrimidine-5-sulfonyl, 2-dimethylamino-pyrimidine-5-sulfonyl, 4-carbamoyl -phenyl-sulfonyl, N-methyl-4-carbamoyl-phenyl-sulfonyl, 2-amino-pyrimidine-5-sulfonyl, 6-methylamino-pyridine-3-sulfonyl, 2-methyl-1H-benzoimidazole-5-sulfonyl, 2-methyl-5-(sulfonyl)-1H-benzoimidazole-1-sulfonic acid, 2-hydroxyethylsulfonyl, 4-methylbenzene-1-sulfinyl, 4-acetamidobenzene-1-sulfinyl, 4-tert-butylbenzene-1-sulfinyl, 3,4-dimethylbenzene-1-sulfinyl, 4-chlorobenzene-1-sulfinyl, p-tolylmethanesulfinyl, 4-fluorobenzene-1-sulfinyl, 3-methylbutane-1-sulfinyl, propane-1-sulfinyl, 4-methoxybenzene-1-sulfinyl, 2-phenylethanesulfinyl, 3,4-dimethoxybenzene-1-sulfinyl, (4-methoxyphenyl)methanesulfinyl, 3,5-dimethylisoxazole-4-sulfinyl, 4-tert-butylbenzene-1-sulfinyl, 2-(pyrazin-2-yl)ethanesulfinyl, 3-methylbenzene-1-sulfinyl, (4-chlorophenyl)methanesulfinyl, cyclopropane-1-sulfinyl, butane-2-sulfinyl, 3,3,3-trifluoropropane-1-sulfinyl, 2-(methylsulfinyl)ethanesulfinyl, ethane-1-sulfinyl, methanesulfinyl, thiazole-2-sulfinyl, 2-methylpropane-1-sulfinyl, 2-methoxyethanesulfinyl, 2,6-dimethylbenzene-1-sulfinyl, 4-trifluoromethoxybenzene-1-sulfinyl, benzo[1,3]dioxole-5-sulfinyl, 2,4-dimethoxyethanesulfinyl, 2-(pyridin-2-yl)ethanesulfinyl, 2-hydroxypropane-1-sulfinyl, prop -2-ene-1-sulfinyl, 5-(methoxymethyl)-1,3,4-thiadiazole-2-sulfinyl, and 2-methylbutane-1-sulfinyl, propane-2-sulfinyl, (2-methyl-tetrahydro-furan-3-sulfinyl, furan-2-ylmethanesulfinyl, [1,3,4]thiadiazole-2-sulfinyl, cyclopentanesulfinyl, 1-methyl-1H-imidazole-2-sulfinyl, benzo[1,3]dioxole-5-sulfinyl, 2-amino-ethanesulfinyl, 4-methoxy-benzenesulfinyl, 2,4-dimethoxyphenylsulfinyl, pyridine-3-sulfinyl, 4-nitro-benzenesulfinyl, 4-amino-benzenesulfinyl, 6-methoxy-pyridine-3-sulfinylmethyl, 2-methoxy-pyrimidine-5-sulfinyl, 2,2-difluoro -benzo[1,3]dioxole-5-sulfinyl, N-trifluoromethyl-4-carbamoyl-phenyl-sulfinyl, 5-methoxy -pyrazine-2-sulfinyl, 5-oxo-4,5-dihydro-pyrazine-2-sulfinyl, 2-oxo-1,2-dihydro-pyrimidine-5-sulfinyl, 6-oxo-1,6-dihydro-pyridine-3-sulfinyl, pyrimidine-2-sulfinyl, 2-methylamino -pyrimidine-5-sulfinyl, 2-dimethylamino-pyrimidine-5-sulfinyl, 4-carbamoyl-phenyl-sulfinyl, N -methyl-4-carbamoyl-phenyl-sulfinyl, 2-amino-pyrimidine-5-sulfinyl, 6-methylamino-pyridine-3-sulfinyl, 2-methyl-1H-benzoimidazole-5-sulfinyl, 2-methyl-5-(sulfinyl)-1H-benzo[d]imidazole -1-sulfonic acid, and 2-hydroxyethylsulfinyl.

15. A compound selected from the group consisting of:

1-(3,4-dichlorobenzyl)-3-(4-(tosylmethyl)thiazol-2-yl)urea;

N-(4-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methylsulfonyl)phenyl)acetamide;

1-(3,4-dichlorobenzyl)-3-(4-((4-(trifluoromethyl)phenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((3,4-dimethylphenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(4-((4-chlorophenylsulfonyl)methyl)thiazol-2-yl)-3-(3,4-dichlorobenzyl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-methylbenzylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-fluorophenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-(isopentylsulfonylmethyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-(propylsulfonylmethyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-methoxyphenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-(phenethylsulfonylmethyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((3,4-dimethoxyphenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-methoxybenzylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((3,5-dimethylisoxazol-4-ylsulfonyl)methyl)thiazol-2-yl)urea;

1-(4-((4-tert-butylphenylsulfonyl)methyl)thiazol-2-yl)-3-(3,4-dichlorobenzyl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((2-(pyrazin-2-yl)ethylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-(m-tolylsulfonylmethyl)thiazol-2-yl)urea;

1-(4-((3,5-dimethylisoxazol-4-ylsulfonyl)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(4-((4-chlorobenzylsulfonyl)methyl)thiazol-2-yl)-3-(3,4-dichlorobenzyl)urea;

1-(3-fluorobenzyl)-3-(4-(propylsulfonylmethyl)thiazol-2-yl)urea;

1-(4-(cyclopropylsulfonylmethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(4-(sec-butylsulfonylmethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(3-fluorobenzyl)-3-(4-((3,3,3-trifluoropropylsulfonyl)methyl)thiazol-2-yl)urea;

1-(4-(butylsulfonylmethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((2-(methylsulfonyl)ethylsulfonyl)methyl)thiazol-2-yl)urea;

1-(4-(ethylsulfonylmethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(3-fluorobenzyl)-3-(4-(m-tolylsulfonylmethyl)thiazol-2-yl)urea;

1-(4-((3,4-dimethoxyphenylsulfonyl)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(3-fluorobenzyl)-3-(4-(methylsulfonylmethyl)thiazol-2-yl)urea;

1-(3-fluorobenzyl)-3-(4-(tosylmethyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((thiazol-2-ylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3-fluorobenzyl)-3-(4-(isobutylsulfonylmethyl)thiazol-2-yl)urea;

N-(4-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methylsulfonyl)phenyl)acetamide;

1-(3,4-dichlorobenzyl)-3-(4-((2-methoxyethylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((2,6-dimethylphenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-(trifluoromethoxy)phenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(4-((benzo[d][1,3]dioxo5-ylsulfonyl)methyl)thiazol-2-yl)-3-(3,4-dichlorobenzyl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((2,4-dimethoxyphenylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((2-(pyridin-2-yl)ethylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3-fluorobenzyl)-3-(4-((2-hydroxypropylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3,5-difluorobenzyl)-3-(4-(propylsulfonylmethyl)thiazol-2-yl)urea;

1-(4-(allylsulfonylmethyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((5-(methoxymethyl)-1,3,4-thiadiazol-2-ylsulfonyl)methyl)thiazol -2-yl)urea;

1-(3-fluorobenzyl)-3-(4-((2-methylbutylsulfonyl)methyl)thiazol-2-yl)urea;

1-(3-fluorobenzyl)-3-(4-(isopropylsulfonylmethyl)thiazol-2-yl)urea;

1-(3-Fluoro-benzyl)-3-[4-(2-methyl-tetrahydro-furan-3- sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(furan-2-ylmethanesulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-([1,3,4]thiadiazole-2-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(4-Cyclopentanesulfonylmethyl-thiazol-2-yl)-3-(3-fluoro-benzyl)-urea;

1-(3-Fluoro-benzyl)-3-[4-(1-methyl-1H-imidazole-2-sulfonylmethyl)-thiazol-2-yl]-urea;

1-[4-(Propane-1 -sulfonylmethyl)-thiazol-2-yl]-3-thiophen-3-ylmethyl-urea;

1-(5-Fluoro-thiophen-2-ylmethyl)-3-[4-(propane-1-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(5-Chloro-thiophen-2-ylmethyl)-3-[4-(propane-1- sulfonylmethyl)-thiazol-2-yl]-urea;

N-(3-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethanesulfonyl }-phenyl)-acetamide;

1-(3-Fluoro-benzyl)-3-[4-(pyridine-3-sulfonylmethyl)-thiazol-2-yl]-urea;

1[4-(Benzo[1,3]dioxole-5-sulfonylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea;

1-[4-(2-Amino-ethanesulfonylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea;

1-(3-Fluoro-benzyl)-3-[4-(4-methoxy-benzenesulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(4-nitro-benzenesulfonylmethyl)-thiazol-2-yl]-urea;

1-[4-(4-Amino-benzenesulfonylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea;

1-(3-Fluoro-benzyl)-3-[4-(6-methoxy-pyridine-3- sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(2-methoxy-pyrimidine-5- sulfonylmethyl)-thiazol-2-yl]-urea;

1-[4-(2,2-Difluoro-benzo[1,3]dioxole-5- sulfonylmethyl)-thiazol-2-yl]-3-(3 -fluoro-benzyl)-urea;

2,2,2-Trifluoro-N-(4-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethanesulfonyl }-phenyl) -acetamide;

1-(3-Fluoro-benzyl)-3-[4-(5-methoxy-pyrazine-2- sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(5-oxo-4,5-dihydro-pyrazine-2-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(2-oxo- 1,2-dihydro-pyrimidine-5-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(6-oxo- 1,6-dihydro-pyridine-3-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(pyrimidine-2-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(2-methylamino-pyrimidine-5- sulfonylmethyl)-thiazol-2-yl]-urea;

1-[4-(2-Dimethylamino-pyrimidine-5-sulfonylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea;

4-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethanesulfonyl}-benzamide;

4-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethanesulfonyl}-N-methyl-benzamide;

1-[4-(2-Amino-pyrimidine-5-sulfonylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea;

1-(3-Fluoro-benzyl)-3-[4-(6-methylamino-pyridine-3-sulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-Fluoro-benzyl)-3-[4-(2-methyl-1H-benzoimidazole-5-sulfonylmethyl)-thiazol-2-yl]-urea;

5-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethanesulfonyl}-2-methyl-benzoimidazole-1-sulfonic acid;

1-(3-Fluoro-benzyl)-3-[5-fluoro-4-(4-methoxy-benzenesulfonylmethyl)-thiazol-2-yl]-urea;

1-(3-((3,5-dimethylisoxazol-4-ylsulfonyl)methyl)-1,2,4-thiadiazol-5-yl)-3-(3-fluorobenzyl)urea;

1-(3-fluorobenzyl)-3-(3-(propylsulfonylmethyl)-1,2,4-thiadiazol-5-yl)urea;

1-(3-fluorobenzyl)-3-(3-((2-hydroxyethylsulfonyl)methyl)-1,2,4-thiadiazol-5-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-(propylsulfinylmethyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((2,6-dimethylphenylsulfinyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-methoxybenzylsulfinyl)methyl)thiazol-2-yl)urea;

1-(3,4-dichlorobenzyl)-3-(4-((4-fluorophenylsulfinyl)methyl)thiazol-2-yl)urea; and

1-(4-((4-chlorophenylsulfinyl)methyl)thiazol-2-yl)-3-(3,4-dichlorobenzyl)urea.

16. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt of a compound of claim 1 .

17. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 15 or a pharmaceutically acceptable salt of a compound of claim 15 .

18. A method for protecting a patient from a bacterial infection comprising administering a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt of a compound of claim 1 to a patient in need thereof.

19. A method for protecting a patient from a bacterial infection comprising administering a therapeutically effective amount of a compound of claim 15 or a pharmaceutically acceptable salt of a compound of claim 15 to a patient in need thereof.