Small molecule inhibitors of Lck SH2 domain binding
The present invention provides materials and methods for modulating an immune response. The materials and methods may be used to treat diseases associated with an aberrant immune response. In some embodiments, materials and methods of the invention may be used to treat autoimmune diseases, for example, rheumatoid arthritis.
1. A method of modulating the activity of Lck kinase in a patient in need thereof, comprising: administering to the patient an effective amount of a compound selected from the group consisting of compounds
2. The method according to claim 1 , wherein the modulation comprises inhibition of binding to ITAM.
3. The method according to claim 1 , wherein the modulation comprises inhibiting kinase activity.
4. The method according to claim 1 , wherein the effective amount is from about 0.01 mg/kg to 10 mg/kg body weight of the patient.
5. The method according to claim 2 , wherein inhibition of binding to ITAM reduces T-cell activation and immune response to provide a treatment for rheumatoid arthritis.