Cells and connecting channels for centrifugal partition chromatography devices
View Patent ↗The present invention relates to cells ( 1 ) for a centrifugal partition chromatography column, consisting of stacked discs and comprising a network of three-dimensional cells interconnected in series and communicating with liquid phase circulation channels, said cells being distributed over the periphery of at least one disc driven into rotation about a main axis ( 8 ); the cells have a geometric shape of revolution about a substantially radial axis with respect to said disc and they are connected by channels ( 2, 4 ) of substantially circular, elliptical or parallelepipedic section, the main two dimensions of which are smaller than the largest cross-section of the cell. The invention also relates to methods of manufacturing these cells.
1. Cells for a centrifugal partition chromatography column including stacked discs, comprising:
a network of three-dimensional cells, wherein the cells are distributed over a periphery of at least one disc driven into rotation about a main axis, the cells have a spherical, spheroid, or ovoid geometric shape of revolution defined by three main dimensions along three axes X-X′, Y-Y′ and Z-Z′, the axis Z-Z′ being parallel to the axis of rotation of the disc, the axis Y-Y′ being radial with respect to the disc, the axis X-X′ being orthogonal to the other two axes, and a cross-section of a cell being perpendicular to the axis Y-Y′ across the axis X-X′ and the axis Z-Z′, wherein each of the cells is formed from a first half cell formed on a first disc and mated with a second half cell formed on a second disc, the first half cell having a structure mirroring the second half cell, and wherein the cells are grouped two by two in series forming pairs of cells; and
liquid phase circulation channels interconnected to, and communicating with, the cells in series, wherein the channels have a substantially circular, elliptical or parallelepipedic section, and the main two dimensions of the section of the channels are smaller than the largest dimensions of the cross-section of the cell, wherein the two cells of each pair of cells are connected to one another by an S-shaped liquid phase circulation channel, and each pair of cells connected with another pair of cells by another S-shaped liquid phase circulation channel.
2. Cells as claimed in claim 1 , whose three dimensions along the three axes X-X′, Y-Y′ and Z-Z′ are substantially identical.
3. Cells as claimed in claim 1 , whose dimension along axis X-X′ is greater than the other two dimensions along axes Z-Z′ and Y-Y′.
4. Cells as claimed in claim 1 , whose dimension along axis Y-Y′ is greater than the other two dimensions along axes Z-Z′ and X-X′.
5. Cells as claimed in claim 1 , whose dimension along axis Z-Z′ is greater than the other two dimensions along axes Y-Y′ and X-X′.
6. Cells as claimed in claim 1 , whose dimensions along axes X-X′, Y-Y′ and Z-Z′ are different.
7. Cells as claimed in claim 1 , characterized in that the cells of each pair of cells are laid out one after the other along axis Y-Y′, and are regularly repeated on a circle parallel to the plane of rotation of disc.
8. Cells as claimed in claim 1 , characterized in that the cells are laid out in at least two concentric circles parallel to the plane of rotation of disc.
9. Cells as claimed in claim 1 , characterized in that the axis made up of the inlet of the liquid phase circulation channels is parallel to axis Y-Y′.
10. Cells as claimed in claim 9 , characterized in that the axis made up of the inlet of the liquid phase circulation channels is superposed on axis Y-Y′.
11. Cells as claimed in claim 9 , characterized in that the axis made up of the inlet of the liquid phase circulation channels is offset with respect to axis Y-Y′.
12. Cells as claimed in claim 1 , wherein the first disc and the second disc are stacked and included in the stacked discs.
13. Cells as claimed in claim 1 , wherein the first disc and the second disc are stacked two by two in the stacked discs.