Macrocyclic compounds and methods of treatment
View Patent ↗The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.
1. A compound according to Formula I:
wherein:
each R is independently H or optionally substituted alkyl;
each R 1 is independently H, or optionally substituted alkyl;
each R 2 is independently H, optionally substituted alkyl, or C(O)R;
each R 3 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
or a pharmaceutically acceptable salt thereof C(O)NRR;
and pharmaceutically acceptable salts, solvate, or hydrate thereof.
2. The compound of claim 1 , wherein R 3 and R 4 are H.
3. The compound of claim 2 wherein R 1 is isopropyl.
4. The compound of claim 1 wherein the compound is any of Compounds 1-8
5. The compound of claim 1 wherein the compound is largazole.
6. The compound of claim 1 , wherein R 2 is alkyl.
7. The compound of claim 6 , wherein R 2 is alkylC(O)—.
8. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
9. The pharmaceutical composition of claim 8 , wherein the compound of claim 1 is any of Compounds 1-8,
and a pharmaceutically acceptable carrier.
10. The pharmaceutical composition of claim 9 further comprising an additional therapeutic agent.
11. The pharmaceutical composition of claim 10 wherein the additional therapeutic agent is an anti-cancer agent, chemotherapeutic agent, an anti-angiogenesis agent, cytotoxic agent, or an anti-proliferation agent.