Inhibitors of janus kinases

1. A compound of the formula I:

wherein D is CR 3 ;

E is N or CR 3 ;

G is CR 3 ;

J is CR 3 ;

L is —NH —;

M is

(a) hydrogen,

(b) halo,

(c) hydroxyl,

(d) C 1-6 alkyl, optionally substituted with one to four substituents independently selected from the group consisting of halo, hydroxyl, SO 2 NR 4 R 5 , Si(CH 3 ) 3 and Si(CH 3 ) 3 O(C 1-6 haloalkyl),

(e) C 2-6 alkenyl,

(f) C 1-6 haloalkyl, which is optionally substituted with C 3-8 cycloalkyl,

(g) C 3-8 cycloalkyl,

(h) (C 1-6 alkyl)C 3-8 cycloalkyl,

(i) aryl, which is optionally substituted with one to four substituents independently selected from the group consisting of halo, hydroxyl, cyano, C 1-6 alkyl which is optionally substituted with one to three substituents independently selected from the group consisting of cyano, halo, hydroxyl and NR 4 R 5 , C 2-6 alkenyl which is optionally substituted with hydroxyl, C 2-6 alkynyl which is optionally substituted with hydroxyl or Si(CH 3 ) 3 , O(C 1-6 haloalkyl), C 3 - 8 cycloalkyl which is optionally substituted with hydroxyl, heteroaryl which is optionally substituted on either the carbon or heteroatom with R 8 , SO m NHR 7 , SO m R 7 , (C 1-6 alkyl)NHSO m R 7 , (C═O)R 8 , (C═O)OR 8 , (C═O)NHR 8 , (C═O)NH-C 1-3 alkyl-heterocyclyl, (C═NH)NHR 8 , (C═NOR 8 )C 1-3 alkyl, (C═NO-C 1-3 alkyl-(C═O)heterocyclyl)C 1-3 alkyl, and (C═NO-C 2-6 alkenyl)C 1-3 alkyl,

(j) heteroaryl, which optionally substituted on either the carbon or heteroatom with one to three substituents independently selected from the group consisting of halo, oxo, aryl and R 8 ;

(k) heterocyclyl,

(l) (C 1-6 alkyl)aryl, which is optionally substituted on either the alkyl or aryl group with a substituent selected from the group consisting of one to two halo and SO m NHR 7 ,

(m) C(O)R 8 , or

(n) NR 4 R 5 ;

R 1 is hydrogen;

R 2 is hydrogen;

R 3 is

(a) hydrogen,

(b) halo,

(c) hydroxyl,

(d) C 1-6 alkyl,

(e) C 2-6 alkenyl, optionally substituted with one to three hydroxyl,

(f) C 2-6 alkynyl, optionally substituted with one to two substituents independently selected from the group consisting of hydroxyl, heteroaryl and NR 4 R 5 ,

(g) C 1-6 haloalkyl,

(h) O(C 1-6 alkyl),

(i) O(C 1-6 haloalkyl),

(j) aryl,

(k) heteroaryl, optionally substituted on either the carbon or heteroatom with one to three substituents independently selected from the group consisting of hydroxyl, R 8 , C 1-6 alkyl(heterocyclyl), CH 2 (C═O)OR 8 and NR 4 R 5 ,

(l) heterocyclyl,

(m) B(OH) 2 ,

(n) NR 4 R 5 ,

(o) NHR 6 or

(p) NH(C═O)R 6 ;

R 4 is hydrogen or C 1-6 alkyl;

R 5 is hydrogen or C 1-6 alkyl;

R 6 is hydrogen, C 1-6 alkyl, NR 4 R 5 , —NH(C 1-6 alkyl)OR 8 , aryl, heteroaryl or heterocyclyl which is optionally substituted on either the carbon or heteroatom with R 8 , wherein said alkyl groups are optionally substituted with one to four substituents selected from hydroxy, halo, OR 8 , NR 8 SO 2 NR 4 R 5 , heteroaryl or heterocyclyl;

R 7 is hydrogen, C 1-6 alkyl, (C 3-6 cycloalkyl), heterocyclyl, (C 1-6 alkyl)heterocyclyl or (C 1-6 alkyl)heteroaryl, wherein said alkyl group is optionally substituted with one to four substituents selected from the group consisting of halo and hydroxy, and said heteroaryl group is optionally substituted with C 1-6 alkyl;

R 8 is hydrogen or C 1-6 alkyl, wherein said alkyl is optionally substituted with one to two hydroxyl; and,

m is an integer from zero to two;

or a pharmaceutically acceptable salt or stereoisomer thereof.

2. The compound of claim 1 , wherein E is N; or a pharmaceutically acceptable salt or stereoisomer thereof.

3. The compound of claim 2 , wherein M is C 1-6 alkyl, optionally substituted with one to four substituents independently selected from the group consisting of halo, hydroxyl and SO 2 NR 4 R 5 ; aryl, which is optionally substituted with one to four substituents independently selected from the group consisting of halo, hydroxyl, cyano, C 1-6 alkyl which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxyl, O(C 1-6 haloalkyl), C 3-8 cycloalkyl which is optionally substituted with hydroxyl, heteroaryl and SO m NHR 7 ; or heteroaryl, which is optionally substituted with halo; or a pharmaceutically acceptable salt or stereoisomer thereof.

4. The compound of claim 3 , wherein M is aryl, which is optionally substituted with one to four substituents independently selected from the group consisting of halo, hydroxyl, cyano, C 1-6 alkyl which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxyl, O(C 1-6 haloalkyl), C 3-8 cycloalkyl which is optionally substituted with hydroxyl, heteroaryl and SO m NHR 7 , or a pharmaceutically acceptable salt or stereoisomer thereof.

5. The compound of claim 2 , wherein R 3 is hydrogen, halo, C 2-6 alkenyl optionally substituted with one to three hydroxyl, C 2-6 alkynyl optionally substituted with one to two substituents independently selected from the group consisting of hydroxyl, heteroaryl and NR 4 R 5 , heteroaryl optionally substituted on either the carbon or heteroatom with one to three substituents independently selected from the group consisting of hydroxyl, R 8 , C 1-6 alkyl(heterocyclyl), CH 2 (C═O)OR 8 and NR 4 R 5 , or B(OH) 2 ; or a pharmaceutically acceptable salt or stereoisomer thereof.

6. The compound of claim 1 selected from:

5-(Cyclopropylamino)-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[(1S)-2-methyl-1-(trifluoromethyl)propyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-[(2,4,6-trifluorophenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(5-tert-Butyl-2-methylphenyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(1,2,2-trimethylpropyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,2-Dimethylpropyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichlorobenzyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5- {[(1R)-2-methyl-1-(trifluoromethyl)propyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2-Chloro-3,6-difluorophenyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[(1S)-1-(trifluoromethyl)propyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[(1R)-1-(trifluoromethyl)propyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[(trimethylsilyl)methyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(1-methylprop-2-en-1-yl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(3,3,3-trifluoro-2-hydroxypropyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2-Chloro-4,6-difluorophenyl)amino]-9-fluorobenzo [c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1R)-1-cyclopropyl-2,2,2-trifluoroethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(1-Ethyl-3,5-dimethyl-1H-pyrazol-4-yl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(5-Tert-butylisoxazol-4-yl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Difluorophenyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1S)-1-(trifluoromethyl)propyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-(methylamino)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-(2,3-Difluorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-(2,5-Difluorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-(3,4-Difluorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[2-(3,4,5-trifluorophenyl)ethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-(3-Chloro-2-fluorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[(1S)-1-(2,6-Dichlorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[(1R)-1-(2,6-Dichlorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1R)-1-(2,6-dichlorophenyl)ethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1S)-1-(2,6-dichlorophenyl)ethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

4-{[(9-Bromo-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]methyl}benzenesulfonamide;

3,5-Dichloro-4-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]benzenesulfonamide;

5-{[2,6-Dichloro-4-(ethylthio)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

4-[(9-Bromo-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-3,5-dichlorobenzenesulfonamide;

9-Bromo-5-[(2-methyl-1-naphthyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-[(2,6-dichlorophenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(4-fluoro-2,6-dimethylphenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2-Chloro-6-methylphenyl)amino]-9-fluorobenzo [c] -2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(2-methyl-1-naphthyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichlorophenyl)amino]-9-fluorobenzo [c]-2,6-naphthyridin-1(2H)-one;

5-[(2-tert-Butylpyridin-4-yl)amino]-9-fluorobenzo [c]-2,6-naphthyridin-1(2H)-one;

3-[(9-Bromo-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-methylbenzonitrile;

9-Bromo-5-[(2,5-dimethylphenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

3-[(9-Bromo-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-chlorobenzonitrile;

5-[(3-tert-Butyl-1-methyl-1H-pyrazol-5-yl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(2-phenylpyridin-4-yl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-[(2-chloro-5-methylphenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(4-Bromo-5-tert-butyl-2-methylphenyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(5-isopropyl-2-methylphenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

2-{3-[(9-Bromo-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-chlorophenyl}-2-methylpropanenitrile;

9-Bromo-5-[(5-tert-butyl-2-methylphenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-Anilino-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-[(5-methyl-1,1-dioxido-2,3-dihydro-1-benzothien-6-yl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,4-Dimethyl-5-(methylsulfonyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(Cyclohexylmethyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[(1R)-1-phenylethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[1-(2,6-Dichlorophenyl)ethyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-(Benzylamino)-9-bromobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1R)-1-phenylethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[(1S)-1-phenylethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[1-(2,6-dichlorophenyl)ethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-[(2-phenylethyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-Chloro-5-(methylsulfonyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[2-fluoro-4-methyl-5-(methylsulfonyl)phenyl]amino}benzo [c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[2-fluoro-5-(methylsulfonyl)phenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(5-Acetyl-2-methylphenyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(5-Acetyl-2-chlorophenyl)amino]-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[5-(1-hydroxyethyl)-2-methylphenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-Chloro-5-(1-hydroxyethyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-Chloro-4-fluoro-5-(1-hydroxyethyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(9-Fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-2,4-dimethyl-N-(pyridin-3-ylmethyl)benzenesulfonamide;

4-[(9-Bromo-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-3,5-dichloro-N-[(1H-methyl-1H -imidazol-2-yl)methyl]benzenesulfonamide;

3,5-Dichloro-4-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-N-isobutylbenzenesulfonamide;

3,5-Dichloro-4-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide;

3,5-Dichloro-4-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzenesulfonamide;

3,5-Dichloro-4-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-N-[(2R)-2-hydroxypropyl]benzenesulfonamide;

5-[(9-Fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-2,4-dimethyl-N-(pyridin-3-ylmethyl)benzenesulfonamide;

5-{[2,4-Dimethyl-5-(morpholin-4-ylsulfonyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,4-Dimethyl-5-(piperidin-1-ylsulfonyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

N-Cyclopropyl-5-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-2,4-dimethylbenzenesulfonamide;

5-[(9-Fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-2,4-dimethyl-N-[(1-methyl-1H-imidazol-2-yl)methyl]benzenesulfonamide;

3-[(9-Fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-methylbenzoic acid;

Methyl 3-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-methylbenzoate;

3-[(9-Fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-N-[(2R)-2-hydroxypropyl]-4-methylbenzamide;

3-[(9-Fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-methyl-N-(morpholin-2-ylmethyl)benzamide;

9-Fluoro-5-{[5-(hydroxymethyl)-2-methylphenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-Bromo-5-{[5-(hydroxymethyl)-2-methylphenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2-Chloro-4-fluoro-5-(hydroxymethyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5-({2-Chloro-5-[5-(hydroxymethyl)-2-furyl]phenyl}amino)-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

1,1,1-Trifluoro-N-{3-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-4-methylbenzyl}methanesulfonamide;

9-(1-Methyl-1H-pyrazol-4-yl)-5-{[(1S)-1-(trifluoromethyl)propyl]amino}bezo[c]-2,6-naphthyridin-1(2H)-one;

5-({2,6-Dichloro-4-[(1R)-1-hydroxyethyl]phenyl}amino)-9-(3-hydroxy-3-methylbut-1-yn-1-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-({2,6-Dichloro-4-[(1S)-1-hydroxyethyl]phenyl}amino)-9-(3-hydroxy-3-methylbut-1-yn-1-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-({2,6-Dichloro-4-[(1R)-1-hydroxyethyl]phenyl}amino)-9-[(3R)-3-hydroxybut-1-yn-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-({2,6-Dichloro-4-[(1S)-1-hydroxyethyl]phenyl}amino)-9-[(3R)-3-hydroxybut-1-yn-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-({2,6-Dichloro-4-[(1R)-1-hydroxyethyl]phenyl}amino)-9-(1-methyl-1H-pyrazol-4-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-({2,6-Dichloro-4-[(1S)-1-hydroxyethyl]phenyl}amino)-9-(1-methyl-1H-pyrazol-4-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}-9-(3-hydroxy-3-methylbut-1-yn-1-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}-9-[(1E)-3-hydroxy-3-methylbut-1-en-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

(5-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl)boronic acid;

9-Bromo-5-{[2,6-dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-hydroxybenzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[2-(1-hydroxy-1-methylethyl)-1,3-thiazol-4-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2-Chloro-4,6-difluorophenyl)amino]-9-(1H-pyrazol-5-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

9-(1-Methyl-1H-pyrazol-4-yl)-5-[(2,4,6- trifluorophenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-(2-Aminopyrimidin-5-yl)-5-[(2,4,6-trifluorophenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-[6-(Hydroxymethyl)pyridin-3-yl]-5-[(2,4,6-trifluorophenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-(1-Methyl-1H-pyrazol-4-yl)-5-{[(1S)-2-methyl-1-(trifluoromethyl)propyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

9-(1H-Pyrazol-5-yl)-5-[(2,4,6-trifluorophenyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[(3R)-3-hydroxybut-1-yn-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[(3S)-3-hydroxybut-1-yn-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}-9-(3-hydroxy-3-methylbut-1-yn-1-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}-9-[(1E)-3-hydroxy-3-methylbut-1-en-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}-9-[(3R)-3-hydroxybut-1-yn-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-(1H-pyrazol-5-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-(1-methyl-1H-pyrazol-4-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-(1,3-thiazol-2-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-(3-hydroxy-3-methylbut-1-yn-1-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[(1E)-3-hydroxy-3-methylbut-1-en-1-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

9-(2-Aminopyrimidin-5-yl)-5-{[2,6-dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-(pyridin-2-ylethynyl)benzo[c]-2,6-naphthyridin-1(2H)-one;

9-(3-Amino-3-methylbut-1-yn-1-yl)-5-{[2,6-dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[1-(1,3-dioxolan-2-ylmethyl)-1H-pyrazol-4-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-(1-isobutyl-1H-pyrazol-4-yl)benzo[c]-2,6-naphthyridin-1(2H)-one;

Ethyl[4-(5-{[2,6-dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl)-1H-pyrazol-1-yl]acetate;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

3,5-Dichloro-4-{[9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl]amino}benzenesulfonamide;

3,5-Dichloro-4-[[1,2-dihydro-9-(1-methyl-1H-pyrazol-4-yl)-1-oxobenzo[c][2,6]napthyridin-5-yl]amino]-benzenesulfonamide;

5-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}-9-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]benzo[c]-2,6-naphthyridin-1(2H)-one;

6-[(2-Chloro-4,6-difluorophenyl)amino]pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-[(2,6-Dichloro-4-fluorophenyl)amino]pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-[(2,4,6-Trifluorophenyl)amino]pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2-Fluoro-6-(Trifluoromethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2,6-Dichloro-4-(trifluoromethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2,6-Dichloro-4-(trifluoromethoxy)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

3,5-Dichloro-4-[(10-oxo-9,10-dihydropyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]benzenesulfonamide;

6-{[(1S)-1-(Trifluoromethyl)propyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[(1S)-2,2,2-Trifluoro-1-methylethyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-[(3,5-Dichloropyridin-4-yl)amino]pyrido[4,3-c]-1,6-naphthyridin10(9H)-one;

4-Methyl-3-[(10-oxo-9,10-dihydropyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]benzonitrile;

6-({2,6-Dichloro-4-[(1R)-1-hydroxyethyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({2,6-Dichloro-4-[(1S)-1-hydroxyethyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

5-{[2-Chloro-5-(1-hydroxy-1-methylethyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

5- {[2-Chloro-4-fluoro-5-(1-hydroxy-1-methylethyl)phenyl]amino}-9-fluorobenzo[c]-2,6-naphthyridin-1(2H)-one;

9-Fluoro-5-{[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

6-{[2,6-Dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one 2-oxide;

6-{[2,6-Dichloro-4-(1H-pyrazol-5-yl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2-Chloro-6-fluoro-4-(1H-pyrazol-5-yl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2,6-Dichloro-4-(1-hydroxycyclopropyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

{3,5-Dichloro-4-[(10-oxo-9,10-dihydropyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]phenyl}(trifluoromethyl)sulfoniumolate;

6-{[2,6-Dichloro-4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({2,6-Dichloro-4-[(1E)-3-hydroxy-3-methylbut-1-en-1-yl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({2,6-Dichloro-4-[(1S)-2,2-difluoro-1-hydroxyethyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({2,6-Dichloro-4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

3,5-Dichloro-4-[(10-oxo-9,10-dihydropyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]benzonitrile;

6-{[4-(1-Amino-1-methylethyl)-2,6-dichlorophenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(91)-one;

5-{[5-(1-Amino-1-methylethyl)-2-methylphenyl]amino}-9-bromobenzo[c]-2,6-naphthyridin-1(2H)-one;

6-({2,6-Dichloro-4-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(91)-one;

6-{[2,6-Dichloro-4-(1H-1,2,3-triazol-4-yl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-{[2-Chloro-6-fluoro-4-(1H-1,2,3-triazol-4-yl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

3,5-Dichloro-4-[(10-oxo-9,10-dihydropyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]benzenecarboximidamide;

6-({2,6-Dichloro-4-[N-ethoxyethanimidoyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({2,6-Dichloro-4-[(N-(2-morpholin-4-y1-2-oxoethoxy)ethanimidoyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({2,6-Dichloro-4-[(N-(2-hydroxy-2-methylpropoxy)ethanimidoyl]phenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({4-[N-(tert-Butoxy)ethanimidoyl]-2,6-dichlorophenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

6-({4-[N-(Allyloxy)ethanimidoyl]-2,6-dichlorophenyl}amino)pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-morpholin-4-ylbenzo[c]-2,6-naphthyridin-1(2H)-one;

4-(2-Hydroxyethyl)-N-{1-oxo-5-[(2,4,6-trifluorophenyl)amino]-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}piperazine-1-carboxamide;

N3-[(Dimethylamino)sulfonyl]-N3-methyl-N-{1-oxo-5-[(2,4,6-trifluorophenyl)amino]-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}-b-alaninamide;

3-Hydroxy-N-{1-oxo-5-[(2,4,6-trifluorophenyl)amino]-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}propanamide;

N-{5-[(2,6-Dichloro-4-fluorophenyl)amino]-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}-2-morpholin-4-ylacetamide;

N-{5-[(2,6-Dichloro-4-fluorophenyl)amino]-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}pyrazine-2-carboxamide;

N-{5-[(2,6-Dichloro-4-fluorophenyl)amino]-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}-N′-(2-methoxyethyl)urea;

N′-{5-[(2,6-Dichloro-4-fluorophenyl)amino]-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}-N,N-dimethylurea;

N-{5-[(2,6-Dichloro-4-fluorophenyl)amino]-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-9-yl}-2-methyl-2-morpholin-4-ylpropanamide;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(2-hydroxy-2-pyrazin-2-ylethyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(2-morpholin-4-ylethyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(3,3,3-trifluoro-2-hydroxypropyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(2,3-dihydroxypropyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(2-hydroxy-3-methoxypropyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-{[2-hydroxy-2-(tetrahydro-2H-pyran-4-yl)ethyl]amino}benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(2-hydroxy-2-pyrazin-2-ylethyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-({[3-(hydroxymethyl)oxetan-3-yl]methyl}amino)benzo[c]-2,6-naphthyridin-1(2H)-one;

5-[(2,6-Dichloro-4-fluorophenyl)amino]-9-[(2-methyl-2-morpholin-4-ylpropyl)amino]benzo[c]-2,6-naphthyridin-1(2H)-one;

or a pharmaceutically acceptable salt or stereoisomer thereof.

7. A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 1 , and a pharmaceutically acceptable carrier.