Methods of treating a
Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.
1. A method of treating a host infected with Hepatitis C virus, the method comprising administering to the host a therapeutically effective amount of an inhibiting agent, or a pharmaceutical salt thereof, to reduce the viral load in the host, wherein the inhibiting agent is a compound having the formula:
wherein R 1 is selected from the group consisting of
R 2 is selected from the group consisting of: —H, —CH 3 , —CF 3 , —CH 2 CH 3 , CH 2 OH,
and
R 4 to R 7 are each independently selected from the group consisting of: —H, —CH 3 , and a halogen.
2. A method of treating HCV replication in a host, comprising administering an inhibiting agent, or a pharmaceutical salt thereof, to the host having an HCV viral infection, wherein the inhibiting agent is a compound having the formula:
wherein R 1 is selected from the group consisting of
R 2 is selected from the group consisting of: —H, —CH 3 , —CF 3 , —CH 2 CH 3 , CH 2 OH,
and
R 4 to R 7 are each independently selected from the group consisting of: —H, —CH 3 , and a halogen.
3. A method of treating liver fibrosis in a host, comprising administering a therapeutically effective amount of an inhibiting agent, or a pharmaceutical salt thereof, to the host, wherein the inhibiting agent is a compound having the formula:
wherein R 1 is selected from the group consisting of
R 2 is selected from the group consisting of: —H, —CH 3 , —CF 3 , —CH 2 CH 3 , CH 2 OH,
and
R 4 to R 7 are each independently selected from the group consisting of: —H, —CH 3 , and a halogen.
4. The method of claim 1 , further comprising administering at least one additional therapeutic agent, wherein the additional therapeutic agent is boceprevir.
5. The method of claim 1 , further comprising administering at least one additional therapeutic agent, wherein the additional therapeutic agent is telaprevir.
6. The method of claim 1 , further comprising administering at least one additional therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: a thiazolide and a sustained release thiazolide.
7. The method of claim 1 , further comprising administering at least one additional therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: an interferon-alpha and a pegylated interferon.
8. The method of claim 1 , further comprising administering at least one additional therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: ribavirin, levovirin, and viramidine.
9. The method of claim 1 , further comprising administering an alpha-glucosidase inhibitor.
10. A method of treating a host infected with Hepatitis C virus, the method comprising administering to the host a therapeutically effective amount of an inhibiting agent, or a pharmaceutical salt thereof, to reduce the viral load in the host, wherein the inhibiting agent is a compound having the formula:
wherein R 1 is
wherein X is a phenyl group or a substituted phenyl group, wherein the substitution moiety is selected from the group consisting of an alkyl group, a halogen, —O-alkyl group, —C(O)—OH group, —C(O)-alkyl group, and a combination thereof;
R 2 is selected from the group consisting of: —H, a halogen, an alkyl group, a substituted alkyl group, a
group wherein X is a phenyl group or a substituted phenyl group, and
group, wherein the substituted alkyl group optionally includes a substitution moiety is selected from a halogen, wherein the substituted phenyl group includes a substitution moiety that is selected from the group consisting of an alkyl group, a halogen, —O-alkyl group, —C(O)—OH group, —C(O)-alkyl group, and a combination thereof; and
R 4 to R 7 are each independently selected from the group consisting of: —H, an alkyl group, and a halogen.
11. The method of claim 10 , further comprising administering at least one additional therapeutic agent, wherein the additional therapeutic agent is boceprevir.
12. The method of claim 10 , further comprising administering at least one additional therapeutic agent, wherein the additional therapeutic agent is telaprevir.
13. The method of claim 10 , further comprising administering at least one additional therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: a thiazolide and a sustained release thiazolide.
14. The method of claim 10 , further comprising administering at least one additional therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: an interferon-alpha and a pegylated interferon.
15. The method of claim 10 , further comprising administering at least one additional therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: ribavirin, levovirin, and viramidine.
16. The method of claim 10 , further comprising administering an alpha-glucosidase inhibitor.