Detection of H. pylori utilizing unlabeled urea
Disclosed is a method and device for detection of H. Pylori in breath emissions utilizing an unlabelled urea, in which a patient ingests a safe quantity of unlabelled urea. After ingestion, expired breath of the patient is analyzed for ammonia, with a detection based on levels of ammonia lower than 50 parts per billion to 500 ppm to detect helicobacter pylori.
1. A method for detection of Helicobacter pylori , the method comprising: ingesting by a patient a safe quantity of unlabelled urea; and analyzing, after the ingestion and after removal of CO 2 , expired breath of the patient for ammonia with a sensor constructed of a metal oxide, wherein the analysis is based on levels of ammonia lower than 50 parts per billion to 500 ppm to detect helicobacter pylori.
2. The method of claim 1 , wherein the detection is not based on 13 CO 2 levels.
3. The method of claim 1 , wherein the analysis is based on an equation:
CO(NH 2 ) 2 +HOH-urease>CO 2 +2NH 3 .
4. The method of claim 1 , wherein the removal of CO 2 is performed with a CO 2 trap.
5. The method of claim 4 , wherein the CO 2 trap is a NaOH trap.
6. The method of claim 1 , wherein the patient is a pediatric patient.