Methods of treating coagulopathy
View Patent ↗The invention provides compositions and methods for enhancing clearance of coagulation factors {e.g., VWF) and platelets from the blood stream of a patient in need thereof. The methods comprise administering to the patient a therapeutically effective amount of an agent that increases clearance of coagulation factors or platelets. Such an agent can be, for example, a neuraminidase.
1. A method of treating coagulopathy in a patient, the method comprising administering to the patient a therapeutically effective amount of a neuraminidase polypeptide that increases clearance of coagulation factors or platelets.
2. The method of claim 1 , wherein the coagulopathy is associated with infection by a pathogen.
3. The method of claim 2 , wherein the pathogen lacks neuraminidase activity.
4. The method of claim 2 , wherein the pathogen has neuraminidase activity.
5. The method of claim 2 , wherein the pathogen is a bacterium.
6. The method of claim 5 , wherein the bacterium is Streptococcus pneumoniae.
7. The method of claim 1 , wherein the coagulopathy is associated with carcinoma, massive tissue injury, snake bite, heat stroke, or liver disease.
8. The method of claim 1 , wherein the coagulopathy is disseminated intravascular coagulation (DIC).
9. The method of claim 1 , wherein the neuraminidase is a bacterial neuraminidase.
10. The method of claim 9 , wherein the neuraminidase is from Arthrobacter ureafaciens.
11. The method of claim 9 , wherein the neuraminidase is from Vibrio cholerae.
12. The method of claim 1 , further comprising administering to the patient a sialyltransferase inhibitor.
13. The method of claim 12 , wherein the sialyltransferase inhibitor inhibits the sialyltransferase ST3Gal IV.
14. The method of claim 12 , wherein the sialyltransferase inhibitor is an analog of a sialyltransferase.