Particles for imaging
The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.
1. A particle comprising an outer layer formed over an inner core, wherein:
a. the inner core is a solution, a mixture, or a suspension that comprises at least one metal atom in the form of an organometallic compound or organo-coated metal compound and a separate polysorbate, wherein the metal atom is selected from the group of metal atoms consisting of metals with an atomic number greater than seventeen and less than eighty-four; and
b. the outer layer comprises an amphiphillic material.
2. The particle of claim 1 , wherein the metal atom is selected from the group consisting of manganese, copper, bismuth, ytterbium and gold.
3. The particle of claim 1 , wherein the outer layer further comprises at least one metal atom.
4. The particle of claim 1 , wherein the particle comprises at least 100,000 metal atoms.
5. The particle of claim 1 , wherein the metal is selected from the group consisting of metals that have a K-edge in the x-ray energy band of CT, metals that have paramagnetic or superparamagnetic properties, metals that have optical, near-infrared, or photoacoustic properties, metals that have sound scattering properties, and metals that have a radioactive particle emission.
6. The particle of claim 1 , wherein the metal atom comprises a metal compound selected from the group consisting of a metal oxide, metal sulphide, metal phosphate, metal carbonate, metal chromate, mixed metal oxide, metal spinels, and a combination thereof.
7. The particle of claim 6 , wherein the metal oxide is selected from the group consisting of magnetite, maghemite, and a combination thereof.
8. The particle of claim 6 , wherein the metal oxide has the formula MFe2O4, where M is selected from the group consisting of Fe, Mn, Co, Ni, Mg, Au, Cu, Zn, Ba, Sr, Pt, Tl, Ti, and a combination thereof.
9. The particle of claim 6 , wherein the mixed metal oxide or spinels is selected from the group consisting of gold oxide, nickel oxide, magnesium oxide, manganese oxide, and cobalt oxide.
10. The particle of claim 1 , wherein the outer layer further comprises one or more molecules selected from the group consisting of a surfactant, a bioactive agent, a targeting agent, and an imaging agent.
11. The particle of claim 10 , wherein the outer layer is comprised of an amphiphilic material selected from the group consisting of natural materials, synthetic materials, semisynthetic materials, and a combination thereof.
12. The particle of claim 10 , wherein the imaging agent is selected from the group of agents detectable by optical imaging, near-infrared imaging, NMR imaging, MRI imaging, x-ray imaging, CT imaging, K-edge imaging, ultrasound imaging, photoacoustic imaging, acoustic optical imaging, microwave imaging, nuclear imaging and combinations thereof.
13. The particle of claim 1 , wherein the organo-coated metal compound of the inner core comprises at least one structure selected from the group consisting of an inverted micelle, a hydrophobically-coated metal particle, and combinations thereof.
14. The particle of claim 13 , wherein the inverted micelle comprises an amphiphilic polymer and metal.
15. The particle of claim 1 , wherein the organometallic compound is selected from the group consisting of metal polysorbate compounds, metal surfactant compounds, metal aliphatic compounds and metal aromatic hydrophobic compounds and combinations thereof.
16. The particle of claim 13 , wherein the hydrophobically-coated metal particle is selected from the group consisting of metal surfactant compounds, metal natural polymer compounds, metal synthetic polymer compounds, metal aliphatic compounds, metal aromatic hydrophobic compounds and combinations thereof.
17. The particle of claim 13 , wherein the inner core is comprised of a plurality of inverted micelles.
18. The particle of claim 17 , wherein the plurality of inverted micelles comprise substantially all the metal atoms comprising the particle.
19. The particle of claim 16 , wherein the metal aliphatic compounds are metal fatty acid compounds.
20. The particle of claim 16 , wherein the metal aliphatic compounds are derived from oleic acid.
21. The particle of claim 20 , wherein the metal aliphatic compound is selected from the group consisting of manganese oleate, copper oleate, bismuth oleate, and yterrbium oleate.