Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer
The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed.
1. A monoclonal antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof specifically binds to a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10.
2. An antibody or antigen-binding fragment thereof as recited in claim 1 , wherein the antibody or antigen-binding fragment thereof is bivalent.
3. An antibody or antigen-binding fragment thereof as recited in claim 1 , wherein the antibody or antigen-binding fragment thereof is monovalent.
4. A composition comprising the antibody or antigen-binding fragment of claim 1 .
5. The composition as recited in claim 4 , which is a pharmaceutical composition and further comprises a pharmaceutically acceptable carrier.
6. A kit comprising: the antibody or antigen-binding fragment thereof according to claim 1 .
7. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the polypeptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10.
8. A monoclonal antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof specifically binds to a peptide consisting of the amino acid sequence set forth at positions 1110-1142 of SEQ ID NO: 10.
9. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the MUC1 polypeptide consisting of the amino acid sequence set forth at positions 1110-1142 of SEQ ID NO: 10.
10. A polyclonal antibody that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the MUC1 polypeptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10, but does not binds to an epitope of the MUC1 polypeptide outside of said region.
11. A polyclonal antibody that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the MUC1 polypeptide consisting of the amino acid sequence set forth at positions 1110-1142 of SEQ ID NO: 10, but does not binds to an epitope of the MUC1 polypeptide outside of said region.
12. A polyclonal antibody produced by immunizing an animal with an immunogen comprising a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10.
13. A polyclonal antibody produced by immunizing an animal with an immunogen comprising a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10, wherein said antibody specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the polypeptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10.