IP Library › Granted Patent US 8,193,309
Granted Patent B2
US 8,193,309 · App. 12/696,603 · Granted Jun 5, 2012

Compositions and methods for preventing or treating cancer

Assignee: Board of Regents of the University of Nebraska
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Quick Facts
Patent No.
US 8,193,309
App. No.
12/696,603
Granted
Jun 5, 2012
Kind
B2
Abstract

The present invention relates to a MUC1 cytoplasmic tail peptide or portion thereof. These peptides are useful for inducing an immune response to MUC1-expressing tumor cells and thus for preventing or treating cancer.

Claims (7)

1. A composition comprising a MUC1 cytoplasmic tail peptide, wherein said MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 49, wherein said MUC1 cytoplasmic tail peptide comprises a sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 14, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 31, SEQ ID NO: 39, SEQ ID NO: 41, and SEQ ID NO: 43.

2. The composition of claim 1 , wherein said MUC1 cytoplasmic tail peptide comprises a sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 21, SEQ ID NO: 25, SEQ ID NO: 28, SEQ ID NO: 39, and SEQ ID NO: 41.

3. The composition of claim 1 further comprising at least one additional MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 1.

4. The composition of claim 3 , wherein said additional MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 47.

5. The composition of claim 3 , wherein said additional MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 48.

6. The composition of claim 1 , wherein said composition comprises more than one of said MUC1 cytoplasmic tail peptides.

7. The composition of claim 1 further comprising a carrier protein.

Assignments (1)
CONFIRMATORY LICENSE Recorded Jun 18, 2012
From: UNIVERSITY OF NEBRASKA MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028390/0290 →
Continuity (2)
Division 10618481 · Jul 11, 2003
Related Publication 20100190720A1 · Jul 29, 2010