Molecule for functionalizing a support, attachment of a radionuclide to the support and radionuclide generator for preparing the radionuclide, and preparation process
Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
1. A generator for a radioactive daughter nuclide comprising
a compound consisting of one of a group consisting of pyrogallol and catechol, and one of a group consisting of a saturated or unsaturated fatty acid having more than 3 carbon atoms, and a branched or straight-chain alkyl chain having more than 3 carbon atoms;
a support selected from the group consisting of an organic support and an inorganic support comprising resin and silica gel, the compound being attached to the support via a nonpolar bond formed between the one of the group consisting of a saturated or unsaturated fatty acid having more than 3 carbon atoms, and a branched or straight-chain alkyl chain having more than 3 carbon atoms, and the support; and
a parent nuclide, which is attached to the one of the group consisting of pyrogallol and catechol.
2. The generator according to claim 1 , where the compound is dodecyl 3,4,5-trihydroxybenzoate.
3. The generator according to claim 1 , wherein the branched or straight-chain alkyl chain having more than 3 carbon atoms is one of an octyl, decyl or octadecyl groups.
4. The generator according to claim 1 wherein said radioactive daughter nuclide is gallium-68 and said parent nuclide is germanium-68.
5. A generator for a radioactive daughter nuclide, comprising:
a compound consisting of dodecyl 3,4,5-trihydroxybenzoate or 2 3-dihydroxynaphthalene;
a support, the compound being attached to the support via a nonpolar bond; and
a parent nuclide, which is attached to the compound via a functional group of the compound.
6. The generator according to claim 5 , where the functional group of the compound comprises a hydroxyl group or a phenolic hydroxyl group.
7. The generator according to claim 5 , where the functional group of the compound is pyrogallol or catechol.
8. The generator according to claim 5 , where the support is selected from the group consisting of an organic support and an inorganic support comprising resin and silica gel.
9. The generator according to claim 8 , where the silica gel is coated with the compound.
10. The generator according to claim 5 , where the nonpolar bond is established by a molecular moiety of the compound.
11. The generator according to claim 10 , where the molecular moiety is hydrophobic.
12. The generator according to claim 10 , where the hydrophobic molecular moiety is selected from the group consisting of:
an aromatic or heteroaromatic moiety;
a saturated or unsaturated fatty acid having more than 3 carbon atoms; and
a branched or straight-chain alkyl chain having more than 3 carbon atoms.