NELL-1 peptides
View Patent ↗Recombinant NELL peptides and methods of preparing the same are disclosed.
1. A composition for inducing bone or cartilage formation comprising: an effective amount of a recombinant Nel-like molecule-1 (NELL-1) peptide comprising the amino acid sequence of SEQ ID NO:2 and a carrier, wherein the carrier comprises a physiologically acceptable compound carrier that forms an implant or scaffold that provides for bone or cartilage formation.
2. The composition of claim 1 , wherein the NELL-1 peptide further comprises a NELL1 or NELL2 secretory peptide.
3. The composition of claim 1 , wherein the carrier is a scaffold.
4. The composition of claim 1 , which is in a formulation for injection into a fracture site or implantation.
5. The composition of claim 1 , further comprising another agent.
6. The composition of claim 5 , wherein the another agent is selected from the group consisting of a bone morphogenetic protein (BMP), a fibroblast growth factor (FGF), a transforming growth factor-β (TGF-β), an insulin-like growth factor (IGF), a vascular endothelial growth factor (VEGF), a platelet-derived growth factor (PDGF), a parathyroid hormone (PTH), a PTH-related protein (PTHrP), growth/differentiation factor 5 (GDF5); and LIM mineralization proteins (LMPs).