IP Library › Patent Application 12714474
Patent Application
App. No. 12/714,474

FOWLICIDINS AND METHODS OF ITS USE

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Quick Facts
Patent No.
US None
App. No.
12/714,474
Abstract

Antimicrobial peptides and methods for their use are provided. The peptides are optimized, truncated versions of chicken cathelicidins (“fowlicidins”).

Claims (11)

1 - 19 . (canceled)

20 . An isolated bactericidal peptide with an amino acid sequence consisting of VWPLV IRTVIAGYNLYRAIKKK (SEQ ID NO: 6) or a truncated bactericidal portion thereof with an amino acid sequence consisting of WPLVIRTVIAGYNLYRAIKKK (SEQ ID NO: 9), or derivatives thereof with conservative amino acid substitutions,

wherein a carboxy terminus of said isolated bactericidal peptide or said truncated bactericidal portion thereof is amidated.

21 . A method of killing or damaging a bacterium, comprising the step of

contacting said bacterium with a bactericidal peptide with an amino acid sequence consisting of VWPLVIRTVIAGYNLYRAIKKK (SEQ ID NO: 6) or a truncated bactericidal portion thereof with an amino acid sequence consisting of WPLVIRTVIAGYNLYRAIKKK (SEQ ID NO: 9), or a derivative thereof with conservative amino acid substitutions,

wherein a carboxy terminus of said bactericidal peptide or said truncated bactericidal portion thereof is amidated, and wherein said bactericidal peptide or said truncated bactericidal portion thereof is provided in a quantity sufficient to kill or damage said bacterium.

22 . The method of claim 21 , wherein said bacterium is an antibiotic resistant bacterium.

23 . A method of treating a bacterial infection in a patient in need thereof, comprising the step of

administering to said patient in a quantity sufficient to treat said bacterial infection, a bactericidal peptide with an amino acid sequence consisting of VWPLVIRTVIAGYNLYRAIKKK (SEQ ID NO: 6) or a truncated bactericidal portion thereof with an amino acid sequence consisting of WPLVIRTVIAGYNLYRAIKKK (SEQ ID NO: 9), or a derivative thereof with conservative amino acid substitutions,

wherein a carboxy terminus of said bactericidal peptide or said truncated bactericidal portion thereof is amidated.

24 . The method of claim 23 , wherein said bacterial infection is caused by an antibiotic resistant bacterium.