Use of IL-6/IL-6 chimera in Huntington's disease
The invention relates to the use of an IL-6R/IL-6 chimera, a mutein, isoform, fused protein, functional derivative, active fraction or circularly permutated derivative or a salt thereof, for the manufacture of a medicament for the treatment and/or prevention of Huntington's disease.
1. A method for attenuating or ameliorating the symptoms of Huntington's disease, comprising administering to a patient in need thereof
an effective amount of an IL-6R/IL-6 chimera, comprising:
a) IL-6R having the sequence of residues 20-356 of SEQ ID NO:2;
b) IL-6 having the sequence of residues 360-543 of SEQ ID NO:2; and
c) optionally, a linker sequence between the sequences of a) and b), said linker sequence having a length of 1-18 residues;
or a functional derivative or salt of said chimera, said chimera being glycosylated at one or more sites.
2. A method according to claim 1 , wherein said IL-6R, IL-6 and optional linker sequence is fused to an immunoglobulin (Ig).
3. A method according to claim 1 , wherein the functional derivative comprises at least one moiety attached to one or more functional groups which occur as one or more side chains on the amino acid residues.
4. A method according to claim 1 , wherein said administering step comprises administering a cell expressing said chimera.