Topical glutathione formulations for menopausal skin
Topical compositions to address menopausal skin conditions comprise an effective amount of S-acyl glutathione derivative and a carrier. Methods for addressing menopausal skin conditions comprise applying a composition containing S-acyl glutathione derivative in a dermatologically acceptable carrier to skin tissue. The acyl group is a saturated or unsaturated aliphatic C 12 -C 24 group, preferably an unsaturated C 16 -C 24 group, most preferably an unsaturated C 18 group. In particularly preferred embodiments, the acyl group is a linoleoyl group.
1. A method of treating spider vessels or red blotchy skin in peri-menopausal, menopausal, or post-menopausal skin comprising: applying to peri-menopausal, menopausal, or post-menopausal skin tissue having spider vessels or red blotchy skin, a composition comprising from 0.1% to 20% by weight of at least one S-acyl glutathione derivative of formula (I)
wherein R1 consists of a saturated or unsaturated aliphatic C12-C24 acyl group and R2 is a hydrogen; and a dermatologically acceptable carrier.
2. The method of claim 1 wherein R1 is an unsaturated C18 acyl group.
3. The method of claim 2 wherein R1 is a linoleoyl or oleoyl group.
4. The method of claim 1 wherein the carrier comprises lecithin.
5. The method of claim 1 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
6. A method of treating spider vessels or red blotchy skin in peri-menopausal, menopausal, or post-menopausal skin comprising: applying to peri-menopausal, menopausal, or post-menopausal skin tissue having spider vessels or red blotchy skin, a composition comprising from 0.1% to 20% by weight of S-linoleoyl glutathione of formula (II)
in a dermatologically acceptable carrier.
7. The method of claim 6 comprising between 0.1% to 5% by weight of S-linoleoyl glutathione.
8. The method of claim 6 comprising from 5% to 20% by weight of S-linoleoyl glutathione.
9. The method of claim 6 wherein said composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives; lipoic acid; α-hydroxy acids; and tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.
10. The method of claim 6 wherein the appearance of spider vessels or red blotchiness is improved.
11. The method of claim 1 , wherein the composition is applied to spider vessels of peri-menopausal, menopausal, or post-menopausal skin.
12. The method of claim 1 , wherein the composition is applied to red blotchiness of peri-menopausal, menopausal, or post-menopausal skin.
13. The method of claim 1 comprising between 0.1% to 5% by weight of S-acyl glutathione derivative.
14. The method of claim 1 comprising from 5% to 20% by weight of S-acyl glutathione derivative.
15. The method of claim 1 wherein the appearance of spider vessels or red blotchiness is improved.