IP Library Granted Patent US 8,414,892
Granted Patent B2
US 8,414,892 · App. 12/721,798 · Granted Apr 9, 2013

Uses of monoclonal antibody 8H9

Inventor: Nai-Kong V. Cheung (New York, NY)
Assignee: Sloan-Kettering Institute for Cancer Research
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Quick Facts
Patent No.
US 8,414,892
App. No.
12/721,798
Granted
Apr 9, 2013
Kind
B2
Abstract

This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

Claims (3)

1. A method for imaging a tumor in a subject, comprising administering to the subject a labeled monoclonal antibody 8H9, wherein the imaging provides information regarding the spatial distribution of absorbed dose within a target volume.

2. The method of claim 1 , wherein the antibody comprises SEQ ID NOs: 29-34.

3. The method of claim 1 , wherein the antibody is radiolabeled.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 19, 2015
From: SLOAN-KETTERING INST CAN RESEARCH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035230/0223 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 27, 2010
From: CHEUNG, NAI-KONG V.
To: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
Reel/Frame 024744/0975 →
Continuity (9)
Division 10505658
Continuation In Part 10273762 · Oct 17, 2002
Continuation In Part 10097558 · Mar 8, 2002
Continuation In Part PCTUS0233331 · Oct 17, 2002
Continuation In Part 10097558 · Mar 8, 2002
Continuation In Part PCTUS0132565 · Oct 18, 2001
Provisional Application 60241344 · Oct 18, 2000
Provisional Application 60330396 · Oct 17, 2001
Related Publication 20100284920A1 · Nov 11, 2010