Compositions and methods for therapy for diseases characterized by defective chloride transport
View Patent ↗Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones, ascorbate and/or derivatives thereof capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis, asthma, and/or another condition responsive to stimulation of chloride transport.
1. A composition comprising:
(a) one or more flavones or isoflavones capable of stimulating chloride secretion;
(b) one or more of:
(i) a compound that increases expression of a CFTR protein in an epithelial cell; and
(ii) a chemical chaperone that increases trafficking of a CFTR protein to a plasma membrane in an epithelial cell;
(c) one or more of a compound selected from the group consisting of ascorbic acid, ascorbate salts, dehydroascorbic acid and resveratrol; and
(d) a physiologically acceptable carrier.
2. The composition of claim 1 wherein the CFTR protein has a mutation at position 551.
3. The composition of claim 1 wherein the CFTR protein has a ΔF508 mutation.