Compositions and Methods for Sparing Muscle in Renal Insufficiency and During Hemodialysis
A nutritional composition and method of use that improves the net balance in skeletal muscle by targeting both the synthetic and breakdown processes. The disclosed composition provides for improved protein intake to increase skeletal muscle protein accretion in stressed patients who are at risk for the development of renal insufficiency by stimulating protein synthesis.
1 . A composition of matter comprising:
An EAA blend, said EAA blend including: valine, threonine, isoleucine, leucine, lysine, phenylalanine, and methionine, and not including glutamine or alanine;
eicosapentaenoic acid (EPA);
a macronutrient blend, said macronutrient blend comprising macronutrients selected from the group consisting of: protein, carbohydrate, and fat; and
a buffering agent.
2 . The composition of claim 1 wherein said EAA blend further comprises arginine and histidine.
3 . The composition of claim 2 wherein:
histidine comprises 1-6% of said EAA blend;
isoleucine comprises 6-15% of said EAA blend;
leucine comprises 15-40% of said EAA blend;
lysine comprises 10-25% of said EAA blend;
methionine comprises 1-5% of said EAA blend;
phenylalanine comprises 5-15% of said EAA blend;
threonine comprises 5-15% of said EAA blend;
valine comprises 5-20% of said EAA blend; and
arginine comprises 5-15% of said EAA blend.
4 . The composition of claim 1 further comprising citrulline.
5 . The composition of claim 1 wherein:
carbohydrate comprises 30-60% of said macronutrient blend;
fat comprises 10-25% of said macronutrient blend; and
protein comprises 25-75% of said macronutrient blend.
6 . The composition of claim 1 wherein said buffering agent comprises sodium bicarbonate.
7 . The composition of claim 1 comprising:
about 15 grams of said EAA blend;
about 1 to about 15 grams of said macronutrient blend;
about 250 to about 1500 milligrams of EPA; and
about 100 to about 700 milligrams of buffering agent.
8 . The composition of claim 1 wherein said macronutrient blend comprises protein peptides.
9 . The composition of claim 1 wherein said macronutrient blend comprises whey protein.
10 . The composition of claim 1 wherein said composition is part of a food product.
11 . The composition of claim 9 wherein said food product comprises a drink.
12 . The composition of claim 1 wherein said composition is part of a pharmaceutical preparation.
13 . A composition of matter consisting essentially of:
valine; threonine; isoleucine; leucine; lysine; phenylalanine; methionine; histidine;
and arginine;
14 . The composition of claim 13 wherein:
histidine comprises 1-6% of said composition;
isoleucine comprises 6-15% of said composition;
leucine comprises 15-40% of said composition;
lysine comprises 10-25% of said composition;
methionine comprises 1-5% of said composition;
phenylalanine comprises 5-15% of said composition;
threonine comprises 5-15% of said composition;
valine comprises 5-20% of said composition; and
arginine comprises 5-15% of said composition.
15 . A composition of matter consisting essentially of:
an EAA blend consisting of: valine, threonine, isoleucine, leucine, lysine, phenylalanine, and methionine; histidine; and arginine;
eicosapentaenoic acid (EPA);
a macronutrient blend consisting of protein; carbohydrate; and fat; and
a buffering agent.
16 . The composition of claim 15 wherein:
histidine comprises 1-6% of said EAA blend;
isoleucine comprises 6-15% of said EAA blend;
leucine comprises 15-40% of said EAA blend;
lysine comprises 10-25% of said EAA blend;
methionine comprises 1-5% of said EAA blend;
phenylalanine comprises 5-15% of said EAA blend;
threonine comprises 5-15% of said EAA blend;
valine comprises 5-20% of said EAA blend; and
arginine comprises 5-15% of said EAA blend.
17 . The composition of claim 15 wherein:
carbohydrate comprises 30-60% of said macronutrient blend;
fat comprises 10-25% of said macronutrient blend; and
protein comprises 25-75% of said macronutrient blend.
18 . The composition of claim 15 wherein said buffering agent comprises sodium bicarbonate.
19 . A method of inhibiting skeletal muscle degradation during renal failure, the method comprising:
administering to said individual a therapeutically effective amount of a composition comprising:
an EAA blend comprising: valine, threonine, isoleucine, leucine, lysine, phenylalanine, and methionine; histidine; and arginine;
eicosapentaenoic acid (EPA);
a macronutrient blend consisting of protein; carbohydrate; and fat; and
a buffering agent; and
administering hemodialysis to said individual.
20 . A composition of matter consisting essentially of:
an EAA blend consisting of valine, threonine, isoleucine, leucine, lysine, phenylalanine, and methionine; histidine; and arginine; and
eicosapentaenoic acid (EPA).