Biocompatible and low-abrasion member, and artificial joint using the same and method of producing the same
The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1 , wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2 , while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
1. A sliding member comprising:
a substrate capable of forming hydroxyl groups; and
a biocompatible material layer laminated on appropriate sections of the substrate,
wherein the hydroxyl groups are formed on at least a required section of a surface of the substrate by surface treating, and the biocompatible material layer is formed from a polymer containing phosphorylcholine groups,
wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica covalently bonded with the hydroxyl groups and the biocompatible material, and
wherein the silica comprises a photopolymerization initiator.
2. The sliding member according to claim 1 , wherein the binder layer is formed through a dehydration-condensation reaction of at least one silicon alkoxide selected from the group of consisting of methacryloyloxypropyltrimethoxysilane, methacryloyloxypropylmethyldimethoxysilane, methacryloyloxypropyltriethoxysilane, and acryloyloxypropyltrimethoxysilane.
3. A prosthesis comprising the sliding member claimed in claim 2 .
4. The sliding member according to claim 1 , wherein the biocompatible material layer is formed from a polymer containing phosphorylcholine groups selected from the group consisting of a poly(2-methacryloyloxyethyl phosphorylcholine) and a copolymer containing 2-methacryloyloxyethyl phosphorylcholine.
5. The sliding member according to claim 4 , wherein the biocompatible material layer is formed in such a manner that the polymer containing the phosphorylcholine groups is covalently bonded as a graft polymer chain.
6. A prosthesis comprising the sliding member claimed in claim 5 .
7. A prosthesis comprising the sliding member claimed in claim 4 .
8. The sliding member according to claim 1 , wherein the substrate is formed from at least one material selected from the group consisting of titanium, a cobalt-chromium alloy, a cobalt-chromium-molybdenum alloy, a nickel-chromium alloy, stainless steel, a titanium base alloy, an alumina containing ceramic, a zirconia containing ceramic, and a titania containing ceramic.
9. A prosthesis comprising the sliding member claimed in claim 8 .
10. The sliding member according to claim 1 , wherein the substrate comprises a chromium component or a titanium component, and
wherein the chromium component or the titanium component at a surface of the substrate is oxidized by an oxygen plasma treatment to form the hydroxyl groups.
11. A prosthesis comprising the sliding member claimed in claim 10 .
12. The sliding member according to claim 1 , which is a hip joint prostheses, a shoulder joint prostheses, a vertebral prostheses, a knee joint prostheses, an elbow joint prostheses, an ankle joint prostheses, a finger joint prostheses, or an artificial disc, and
wherein the substrate is formed from a ceramic or a cobalt-chromium alloy.
13. A prosthesis comprising the sliding member claimed in claim 12 .
14. A prosthesis comprising the sliding member claimed in claim 1 .
15. A sliding member comprising:
a substrate capable of forming hydroxyl groups; and
a biocompatible material layer laminated on appropriate sections of the substrate,
wherein the hydroxyl groups are formed on at least a required section of a surface of the substrate by surface treating, and the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and has a thickness from 10 to 200 nm,
wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica covalently bonded with the hydroxyl groups and the biocompatible material, and
wherein the silica comprises a photopolymerization initiator.
16. The sliding member according to claim 15 , wherein the biocompatible material layer has a thickness from 100 to 200 nm.
17. A prosthesis comprising the sliding member claimed in claim 16 .
18. The sliding member according to claim 15 , wherein the biocompatible material layer has wettability defined as a contact angle of 30° or less of the biocompatible material layer to water.
19. The sliding member according to claim 18 , wherein the phosphorylcholine groups have a concentration of phosphorus atoms measured by an X-ray photoelectron spectroscopy in a sliding surface of 4.6 atomic % or more.
20. A prosthesis comprising the sliding member claimed in claim 19 .
21. A prosthesis comprising the sliding member claimed in claim 18 .
22. A prosthesis comprising the sliding member claimed in claim 15 .
23. The sliding member according to claim 15 , which is a hip joint prostheses, a shoulder joint prostheses, a vertebral prostheses, a knee joint prostheses, an elbow joint prostheses, an ankle joint prostheses, a finger joint prostheses, or an artificial disc, and
wherein the substrate is formed from a ceramic or a cobalt-chromium alloy.