Anti-inflammatory agents
This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating or preventing various inflammatory conditions. In particular, the invention relates to compositions and methods for treating or preventing inflammatory conditions such as citrulline-related inflammatory diseases. The invention provides specific binding molecules directed against citrulline-containing epitopes for use in the therapy and prevention of inflammatory conditions.
1. A method of treating rheumatoid arthritis in a subject diagnosed with rheumatoid arthritis, the method comprising:
administering to the subject an antibody that binds a citrullinated epitope on the peptide of SEQ ID NO: 21.
2. The method according to claim 1 , wherein the antibody is a monoclonal antibody, a recombinant antibody, or a single chain antibody.
3. The method according to claim 1 , wherein the antibody comprises the variable heavy chain of SEQ ID NO: 13 and the variable light chain of SEQ ID NO: 15.
4. A method of treating rheumatoid arthritis in a subject diagnosed with rheumatoid arthritis, the method comprising:
administering to the subject an antibody having polypeptide sequences identical to those of RhmAb2.102.