Oral care compositions for treating xerostomia

1. A method of treating xerostomia comprising administering to a subject in need thereof an effective amount of an oral care composition comprising (1) 10 mg/unit to 100 mg/unit of green tea extract comprising at least one green tea polyphenol (GTP) or a pharmaceutically acceptable salt or ester thereof and (2) 5 mg/unit to 50 mg/unit of Jaborandi extract.

2. The method of claim 1 , wherein the subject has an autoimmune disease.

3. The method of claim 1 , wherein the subject has Sjögren's syndrome.

4. The method of claim 1 , wherein the subject has recently undergone radiation or chemotherapy.

5. The method of claim 1 , wherein the subject has diabetes.

6. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

wherein R 1 is H, OH or gallic acid (GA);

R 3 is OH;

n is from 1to 5; and

the stereochemistry at carbon a is substantially R or S.

7. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

wherein R 1 is H, OH or gallic acid (GA), and

wherein R 2 is OH or H.

8. The method of claim 1 , wherein the GTP is epigallocatechin-3-gallate (EGCG) or the pharmaceutically acceptable salt or ester thereof.

9. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

10. The method of claim 1 , wherein the GTP is epigallocatechin (EGC) or the pharmaceutically acceptable salt or ester thereof.

11. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

12. The method of claim 1 , wherein the GTP is epicatechin gallate (ECG) or the pharmaceutically acceptable salt or ester thereof.

13. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

14. The method of claim 1 , wherein the GTP is epicatechin (EC) or the pharmaceutically acceptable salt or ester thereof.

15. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

16. The method of claim 1 , wherein the GTP is catechin (+C) or the pharmaceutically acceptable salt or ester thereof.

17. The method of claim 1 , wherein the GTP has the following chemical structure or the pharmaceutically acceptable salt or ester thereof:

18. The method of claim 1 , wherein the Jaborandi extract comprises pilocarpine.

19. The method of claim 1 , wherein the oral care composition comprises at least one taste stimulating component.

20. The method of claim 19 , wherein the at least one taste stimulating component is citric acid, isocitric acid, malic acid, acetic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, maleic acid, fumaric acid, aconitic acid, lactic acid, tartaric acid, pyruvic acid, ascorbic acid, aldonic acid, uronic acid, sodium glutamate, inosinic acid, or any combination thereof.

21. The method of claim 19 , wherein the at least one taste stimulating component is citric acid.

22. The method of claim 1 , wherein the oral care composition further comprises xylitol.

23. The method of claim 1 , wherein the oral care composition is a dentifrice preparation.

24. The method of claim 1 , wherein the oral care composition further comprises an orally acceptable carrier or excipient.

25. The method of claim 1 , wherein the oral care composition comprises 10 mg/unit to 100 mg/unit of the one or more GTPs.

26. The method of claim 1 , further comprising an orally acceptable carrier or excipient.

27. The method of claim 1 , wherein the composition comprises 100 mg/unit green tea extract.

28. The method of claim 1 , wherein the composition comprises 20 mg/unit of Jaborandi extract.

29. The method of claim 27 , wherein the composition comprises 20 mg of Jaborandi extract.