Bone resorption inhibitory food material for inhibiting bone resorption
A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.
1. A milk protein fraction having following characteristics (1) to (5):
(1) the milk protein fraction is derived from milk,
(2) the milk protein fraction contains proteins having a molecular weight of 12,000 to 16,000 daltons determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE),
(3) the milk protein fraction contains 18 to 20 percent of basic amino acids by weight of the constituent amino acid composition, and has a basic amino acid/acidic amino acid ratio of 0.7 to 0.9,
(4) the milk protein fraction has a bone resorption inhibitory effect, and
(5) the milk protein fraction has an isoelectric point of 10 or more.
2. A milk protein fraction degradation product obtained by degrading the milk protein fraction according to claim 1 with at least one of pepsin, trypsin, or pancreatin.
3. A bone resorption inhibitory agent comprising the milk protein fraction according to claim 1 .
4. A bone resorption inhibitory pharmaceutical comprising the milk protein fraction according to claim 1 .
5. A bone resorption inhibitory food or drink comprising the milk protein fraction according to claim 1 .
6. A bone resorption inhibitory feed comprising the milk protein fraction according to claim 1 .
7. A bone resorption inhibitory agent comprising the milk protein fraction degradation product according to claim 2 .
8. A bone resorption inhibitory pharmaceutical comprising the milk protein fraction degradation product according to claim 2 .
9. A bone resorption inhibitory food or drink comprising the milk protein fraction degradation product according to claim 2 .
10. A bone resorption inhibitory feed comprising the milk protein fraction degradation product according to claim 2 .
11. A method of inhibiting bone resorption in the body of a human or animal, comprising administering an effective amount of the milk protein fraction of claim 1 to the human or animal.