FOOD MATERIAL FOR INHIBITING OSTEOCLASTOGENESIS
Disclosed is an osteoclastogenesis inhibitory agent which comprises a milk protein fraction having the following properties (1) to (4) and the agent is excellent in an osteoclastogenesis inhibitory effect and useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 80,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 16 to 18 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.65 to 0.85; and (4) the milk protein fraction has an osteoclastogenesis inhibitory effect .
1 . A milk protein fraction having following characteristics (1) to (4);
(1) the milk protein fraction is derived from milk,
(2) the milk protein fraction contains proteins having a molecular weight of 80,000 to 85,000 daltons determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE),
(3) the milk protein fraction contains 16 to 18 wt % of basic amino acids in the constituent amino acid composition, and has a basic amino acid/acidic amino acid ratio of 0.65 to 0.85, and
(4) the milk protein fraction has an osteoclastogenesis inhibitory effect.
2 . A milk protein fraction degradation product obtained by degrading the milk protein fraction according to claim 1 with a protease.
3 . An osteoclastogenesis inhibitory agent comprising the milk protein fraction according to claim 1 .
4 . A pharmaceutical for inhibiting osteoclastogenesis comprising the milk protein fraction according to claim 1 .
5 . A food or drink for inhibiting osteoclastogenesis comprising the milk protein fraction according to claim 1 .
6 . A feed for inhibiting osteoclastogenesis comprising the milk protein fraction according to claim 1 .
7 . An osteoclastogenesis inhibitory agent comprising the milk protein fraction degradation product according to claim 2 .
8 . A pharmaceutical for inhibiting osteoclastogenesis comprising the milk protein fraction degradation product according to claim 2 .
9 . A food or drink for inhibiting osteoclastogenesis comprising the milk protein fraction degradation product according to claim 2 .
10 . A feed for inhibiting osteoclastogenesis comprising the milk protein fraction degradation product according to claim 2 .