FOOD MATERIAL FOR PROMOTING THE DIFFERENTIATION OF OSTEOBLAST AND INHIBITING THE DIFFERENTIATION OF OSTEOCLAST
Disclosed is an osteoblast differentiation promoting and osteoclast differentiation inhibiting agent which comprises a milk protein fraction having the following characteristics (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 75,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 13 to 15 wt % in the constitutional amino acid composition, and has a basic amino acid/acidic amino acid of 0.5 to 0.7; and (4) the milk protein fraction has an osteoblast differentiation promoting effect and an osteoclast differentiation inhibiting.
1 . A milk protein fraction having following characteristics (1) to (4); (1) the milk protein fraction is derived from milk, (2) the milk protein fraction contains proteins having a molecular weight of 75,000 to 80,000 daltons determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), (3) the milk protein fraction contains 13 to 15 wt % of basic amino acids in the constituent amino acid composition, and has a basic amino acid/acidic amino acid ratio of 0.5 to 0.7, and (4) the milk protein fraction has an osteoblast differentiation promoting effect and an osteoclast differentiation inhibiting.
2 . A milk protein fraction degradation product obtained by degrading the milk protein fraction according to claim 1 with a protease.
3 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting agent comprising the milk protein fraction according to claim 1 .
4 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting pharmaceutical comprising the milk protein fraction according to claim 1 .
5 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting food or drink comprising the milk protein fraction according to claim 1 .
6 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting feed comprising the milk protein fraction according to claim 1 .
7 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting agent comprising the milk protein fraction degradation product according to claim 2 .
8 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting pharmaceutical comprising the milk protein fraction degradation product according to claim 2 .
9 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting food or drink comprising the milk protein fraction degradation product according to claim 2 .
10 . An osteoblast differentiation promoting and osteoclast differentiation inhibiting feed comprising the milk protein fraction degradation product according to claim 2 .