Combination of anti-angiogenic substance and anti-tumor platinum complex
The problems of the present invention are to find a pharmaceutical composition and a method for treating cancer that exhibit excellent anti-tumor effect. Excellent anti-tumor effect is achieved when 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy- 6 quinolinecarboxamide or an analogous compound thereof, a pharmacologically acceptable salt thereof or a solvate thereof is used in combination with an anti-tumor platinum complex.
1. A pharmaceutical composition comprising a combination of:
(i) 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, a pharmacologically acceptable salt thereof or a solvate thereof; and
(ii) cisplatin or carboplatin.
2. The pharmaceutical composition according to claim 1 , wherein the 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, pharmacologically acceptable salt thereof or solvate thereof is a methanesulfonate of 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.
3. A pharmaceutical composition comprising:
4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, a pharmacologically acceptable salt thereof or a solvate thereof that is simultaneously or separately administered to a patient with an anti-tumor platinum complex selected from the group consisting of cisplatin or carboplatin.
4. The pharmaceutical composition according to claim 3 , wherein the 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, pharmacologically acceptable salt thereof or solvate thereof is a methanesulfonate of 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.
5. A method for treating lung cancer characterized by simultaneously or separately administering, to a patient in need thereof, an effective amount of:
(i) 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, a pharmacologically acceptable salt thereof or a solvate thereof; and
(ii) an anti-tumor platinum complex selected from the group consisting of cisplatin or carboplatin.
6. A method according to claim 5 , wherein the 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide, pharmacologically acceptable salt thereof or solvate thereof is a methanesulfonate of 4-(3-chloro-4-(cyclopropyloaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.