IP Library › Granted Patent US 9,539,327
Granted Patent B2
US 9,539,327 · App. 12/744,831 · Granted Jan 10, 2017

Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells

Inventors: Matthew R. Pincus (Brooklyn, NY); Josef Michl (Little Neck, NY); Ehsan Sarafraz-Yazdi (New York, NY)
Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
A61K45/06A61K31/155A61K31/4995A61K38/10A61K38/1709A61K38/1758A61K47/48023C07K14/4746C07K2319/03
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Quick Facts
Patent No.
US 9,539,327
App. No.
12/744,831
Granted
Jan 10, 2017
Kind
B2
Abstract

A method of treating cancer in a subject, including: providing a subject having a plurality of cancer cells; and administering to the subject, a therapeutically effective amount of a composition including: an HDM-2 binding component; and a membrane resident component, the membrane resident component bound to the HDM-2 binding component. Also provided are a method of selectively necrosing cancer cells, a method of causing membranolysis in cancer cells, and a cancer treatment composition.

Claims (9)

1. A method of treating cancer in a subject, said method comprising:

providing a subject having a plurality of cancer cells; and

administering to the subject, a therapeutically effective amount of a composition including:

an HDM-2 binding component comprising:

and

a membrane resident component comprising:

said membrane resident component bound to said HDM-2 binding component.

2. The method of claim 1 , further comprising the step of observing necrosis in the cancer cells.

3. The method of claim 1 , whereby the cancer cells are necrosed.

Assignments (3)
CHANGE OF NAME Recorded Nov 7, 2016
From: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
To: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Reel/Frame 040575/0370 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2014
From: SARAFRAZ-YAZDI, EHSAN
To: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
Reel/Frame 033354/0744 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 9, 2010
From: PINCUS, MATTHEW R.; MICHL, JOSEF
To: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
Reel/Frame 025484/0141 →
Continuity (2)
Provisional Application 60990276 · Nov 26, 2007
Related Publication 20110183915A1 · Jul 28, 2011