Activated T Cells
Provided are compositions comprising activated T cells and activated T cells armed with bispecific antibodies directed at cancer antigens which are poor responders to alloantigen, and methods of using the compositions to help engraftment and improve anti-tumor effects.
1 . A composition comprising cord blood mononuclear cells wherein said cord blood mononuclear cells do not react to allo-antigens on other cord bloods.
2 . A composition according to claim 1 wherein said cord blood mononuclear cells include cord blood T cells and other mononuclear cell components in cord blood.
3 . A composition according to claim 2 wherein said cord blood T cells include anti-CD3 activated cord blood T and said mononuclear cell components include activated mononuclear cell components.
4 . A composition according to claim 3 wherein said anti-CD3 activated cord blood T cells and other activated mononuclear cell components in cord blood do not react to allo-antigens on human adult peripheral blood mononuclear cells as well as non-cord-blood tissues.
5 . A composition for providing helper activity to facilitate engraftment comprising cord blood T cells and/or other non-lymphoid activated cord blood cell components.
6 . A composition according to claim 5 wherein said T cells are activated T cells.
7 . A composition according to claim 5 wherein said T cells are irradiated cord blood T cells.
8 . A composition according to claim 6 wherein said T cells are irradiated cord blood T cells.
9 . A composition according to claim 5 further comprising a bispecific antibody targeted to bone marrow.
10 . A composition according to claim 9 wherein said T cells are activated cord blood T cells.
11 . A composition for facilitating engraftment comprising activated or non-activated mesenchymal stromal cells from cord blood and a bispecific antibody targeted to bone marrow.
12 . A composition according to claim 2 wherein said cord blood T cells and other mononuclear cell components in cord blood do not react to allo-antigens in adult peripheral blood on other cord bloods.