Gamma secretase modulators
View Patent ↗This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula [Chemical formula should be inserted here as it appears on abstract in electronic form.] Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof,
wherein R 1 is an alkyl group substituted with one phenyl, wherein the phenyl is optionally substituted with 1-3 halo or one SF 5 group;
R 2 is hydrogen or alkyl; and
R 21 is hydrogen or halo.
2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the alkyl group of R 1 is methyl or ethyl.
3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the phenyl of R 1 is substituted with 1-3 fluoro.
4. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 2 is methyl.
5. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 21 is chloro.
6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
8. A pharmaceutical composition comprising a compound according to claim 6 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.