Antiadhesion agents
Vitamin E succinate derivatives according to formula I: are described. These compounds can be included in pharmaceutical compositions, and can be used for the treatment of cancers such as metastatic cancer and as antiadhesive agents.
1. A compound according to formula (I):
wherein R is independently selected from hydrogen and methyl; R 1 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, non-1-enyl, and non-8-enylnitrile groups; and n is an integer from 1 to 7, or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein n is 1 or 2.
3. The compound of claim 1 , wherein R 1 is a 4,8-dimethyl-non-1-enyl group.
4. The compound of claim 1 , wherein R 1 is a non-1-enyl group.
5. The compound of claim 1 , wherein R 1 is a non-8-enylnitrile group.
6. A method of treating cancer in a subject, comprising administering a therapeutically effective amount of a pharmaceutical composition including a compound of Formula (I):
wherein R is independently selected from hydrogen and methyl; R 1 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, non-1-enyl, and non-8-enylnitrile groups; and n is an integer from 1 to 7, or a pharmaceutically acceptable salt thereof.
7. The method of claim 6 , wherein the cancer is metastatic cancer.
8. The method of claim 6 , wherein R 1 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, non-1-enyl, and non-8-enylnitrile.
9. The method of claim 6 , wherein n is 1 or 2.
10. The method of claim 6 , wherein n is 1 and R 1 is 4,8-dimethyl-non-1-enyl.
11. A method of inhibiting cell adhesion in a subject in need thereof by administering a therapeutically effective amount of a pharmaceutical composition including a compound of Formula (I):
wherein R is independently selected from hydrogen and methyl; R 1 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, non-1-enyl, and non-8-enylnitrile groups; and n is an integer from 1 to 7, or a pharmaceutically acceptable salt thereof.
12. The method of claim 11 , wherein n is 1 or 2.
13. The method of claim 11 , wherein n is 1 and R 1 is 4,8-dimethyl-non-1-enyl.