Pharmaceutical formulations comprising neurotrophin mimetics
Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75 NTR receptor molecule. Enhanced survival of neural and other cells has been observed.
1. A pharmaceutical formulation comprising a unit dose of an active ingredient and a pharmaceutical grade carrier, wherein said active ingredient is selected from the group consisting of a compound having the structure:
wherein:
m is an integer from 1 to 8;
R 3 is selected from the group consisting of H, alkyl, cycloalkyl, halo, hydroxyl, alkoxyl, aryloxyl, and aralkyloxyl; and
R 5 and R 6 are each independently selected from the group consisting of H, alkyl, cycloalkyl, aryl, hydroxyl, alkoxyl, hydroxyalkyl, hydroxycycloalkyl, alkoxycycloalkyl, aminoalkyl, acyloxyl, alkylaminoalkyl, and alkoxycarbonyl;
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical formulation comprising a unit dose of an active ingredient and a pharmaceutical grade carrier, wherein said active ingredient is a compound having the structure:
or a pharmaceutically acceptable salt thereof.
3. The pharmaceutical formulation of claim 1 , wherein said formulation is a liquid solution, suspension, emulsion, tablet, pill, or capsule.
4. The pharmaceutical formulation of claim 3 , formulated for administration to a human.
5. The pharmaceutical formulation of claim 2 , wherein said formulation is a liquid solution, suspension, emulsion, tablet, pill, or capsule.
6. The pharmaceutical formulation of claim 5 , formulated for administration to a human.