Antibodies for amyloid specific peptides
View Patent ↗Phage peptide display technology was used to identify peptides that bind specifically to the amyloid form of the Aβ 1-40 peptide. Peptides with similar structural features and bind to the amyloid form of Aβ 1-40 but not to monomeric Aβ 1-40 , are provided. Such peptides are useful as carrier molecules to deliver therapeutic and diagnostic reagents to amyloid plaques.
1. An antibody that binds to a polypeptide consisting of the amino acid sequence as set forth in SEQ ID NO:5.
2. An antibody that binds to a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:5, wherein the antibody specifically binds to epitopes within the amino acid sequence of SEQ ID NO:5.
3. The antibody of claim 1 or 2 , that binds to a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:4, wherein the antibody specifically binds to epitopes within the amino acid sequence of SEQ ID NO:4.
4. The antibody of claim 3 , that binds to a polypeptide consisting of the amino acid sequence as set forth in SEQ ID NO:4.
5. The antibody of claim 3 , wherein the polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:4 further comprises from one to twenty additional amino acids at the N-terminus, wherein the antibody specifically binds to epitopes within the amino acid sequence of SEQ ID NO:4.