IP Library › Granted Patent US 8,614,185
Granted Patent B2
US 8,614,185 · App. 12/768,093 · Granted Dec 24, 2013

Fusion proteins of alpha-MSH derivatives and Fc

Inventor: George Heavner (Radnor, PA)
Assignee: Centocor Ortho Biotech Inc.
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Quick Facts
Patent No.
US 8,614,185
App. No.
12/768,093
Granted
Dec 24, 2013
Kind
B2
Abstract

The present invention relates to melanocortin receptor binding conjugates and methods of making and using the foregoing.

Claims (4)

1. An alpha-MSH derivative-Fc conjugate,

wherein the alpha-MSH derivative has a structure shown in Formula X (SEQ ID NO: 18), and the alpha-MSH derivative is coupled to the Fc via a hydrazine linker.

2. The alpha-MSH derivative-Fc conjugate of claim 1 , wherein the Fc is derived from an IgG1 Fc of SEQ ID NO: 2 or an IgG4 Fc of SEQ ID NO: 3.

3. A pharmaceutical composition comprising the alpha-MSH derivative-Fc conjugate of claim 1 in combination with a pharmaceutically acceptable carrier.

Assignments (2)
CHANGE OF NAME Recorded Oct 23, 2013
From: CENTOCOR ORTHO BIOTECH INC.
To: JANSSEN BIOTECH, INC.
Reel/Frame 031476/0611 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2010
From: HEAVNER, GEORGE
To: CENTOCOR ORTHO BIOTECH INC.
Reel/Frame 024722/0781 →
Continuity (3)
Provisional Application 61175921 · May 6, 2009
Provisional Application 61176294 · May 7, 2009
Related Publication 20100278845A1 · Nov 4, 2010