Granted Patent
B2
US 8,440,204 · App. 12/769,754 · Granted May 14, 2013
Subtype of
Inventors:
Eric A. Johnson (Madison, WI); Mark Joseph Jacobson (Madison, WI); Guangyun Lin (Madison, WI); Raymond C. Stevens (La Jolla, CA); Jerome Dupuy (Saint Quentin sur Isere, FR); P{dot over (a)}l Erik Gustav Stenmark (Stockholm, SE); William H. Tepp (Stoughton, WI)
View Patent ↗
Loading inventors, assignments & file history…
Abstract
A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.
Claims (3)
1. A substantially purified BoNT/Az5 protein, wherein the protein is encoded by the nucleotide comprising SEQ ID NO:1 or by a nucleotide sequence at least 99% identical with SEQ ID NO:1.
2. The BoNT/A5 protein of claim 1 , wherein the purity of the protein is at least 90%.
3. The BoNT/A5 protein of claim 1 , wherein the purity of the protein is at least 95%.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 19, 2010
From: STEVENS, RAYMOND C.; DUPUY, JEROME; STENMARK, PAL
To: SCRIPPS RESEARCH INSTITUTE, THE
Reel/Frame 024704/0371 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 8, 2010
From: JOHNSON, ERIC; JACOBSON, MARK; LIN, GUANGYUN; TEPP, WILLIAM
To: WISCONSIN ALUMNI RESEARCH FOUNDATION
Reel/Frame 024502/0233 →
CONFIRMATORY LICENSE
Recorded May 3, 2010
From: UNIVERSITY OF WISCONSIN MADISON
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024322/0780 →
Continuity (2)
Provisional Application
61174331
· Apr 30, 2009