Granted Patent
B2
US 8,524,682 · App. 12/778,739 · Granted Sep 3, 2013
Compositions and methods for inhibiting EZH2
Inventors:
Arul M. Chinnaiyan (Plymouth, MI); Sooryanarayana Lnu (Ann Arbor, MI); Qi Cao (Ann Arbor, MI)
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Abstract
The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
Claims (4)
1. A method of inhibiting the growth of cells, comprising contacting a cancer cell selected from the group consisting of a prostate cancer cell, a breast cancer cell, and bladder cancer cell overexpressing EZH2 with miR-101 under conditions such that the expression of EZH2 in said cancer cell is inhibited.
2. The method of claim 1 , wherein said cell is in an organism.
3. The method of claim 2 , wherein said organism is an animal.
4. The method of claim 3 , wherein said animal has been diagnosed with cancer.
Assignments (1)
CONFIRMATORY LICENSE
Recorded Jun 1, 2010
From: UNIVERSITY OF MICHIGAN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024461/0196 →
Continuity (3)
Provisional Application
60958151
· Jul 3, 2007