Implant and method for manufacturing same
The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NO X into the cavities of the pore structure. Also described is an implant manufactured in this manner.
1. A method for manufacturing a vascular implant, having a body containing metallic material comprising the following steps:
i) providing the body of the implant;
ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface, comprising a reducing step followed by an annealing step in an oxidizing atmosphere, wherein the pore structure comprises microscopic structures having a diameter of less than 1 μm; and
iii) incorporating NO x into the cavities of the pore structure.
2. The method according to claim 1 , wherein the reducing step comprises heat treatment of the implant body in a carbon-containing atmosphere.
3. The method according to claim 1 , wherein the NO x is incorporated into the pore structure by applying a gauge pressure of at least 5 bar or at least 8 bar.
4. The method according to claim 1 , wherein after step iii) the implant body is coated, at least on a portion of its surface, with a polymer.
5. The method according to claim 1 , wherein the body of the implant is greater than 90% by weight iron or greater than 99% by weight iron.
6. The method according to claim 1 , wherein the pore structure has a maximum depth of 15 μm.
7. The method according to claim 6 , wherein the pore structure has a depth between 10 μm to 15 μm.
8. The method according to claim 1 , wherein the step of producing at least one partially closed pore structure further comprises a vacuum annealing step after oxidation from the oxidizing atmosphere.
9. The method according to claim 8 , wherein the reducing step, annealing step, vacuum annealing step and step of incorporating NO x is performed in a same treatment chamber.
10. The method according to claim 1 , wherein the reducing step, annealing step and step of incorporating NO x is performed in a same treatment chamber.
11. The method according to claim 1 , wherein the vascular implant is an intraluminal endoprosthesis.
12. The method according to claim 1 , wherein the implant comprises an iron alloy.
13. The method according claim 4 , wherein the polymer is selected from the group consisting of magnesium stearate, parylene, and a pharmaceutically active substance.