IP Library › Patent Application 12793787
Patent Application
App. No. 12/793,787

Desiccated Biologics And Methods Of Preparing The Same

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Quick Facts
Patent No.
US None
App. No.
12/793,787
Abstract

The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of preparing the same, and to methods of treating animals using the same.

Claims (19)

1 . A composition comprising:

one or more biologics;

one or more membrane penetrable sugars; and

one or more membrane impenetrable sugars;

wherein the moisture content of the composition is from about 5% to about 95%.

2 . The composition of claim 1 wherein the biologic is a cell.

3 . The composition of claim 2 wherein the cell is anucleated.

4 . The composition of claim 3 wherein the anucleated cell is a platelet or red blood cell.

5 . The composition of claim 2 wherein the cell is nucleated.

6 . The composition of claim 5 wherein the nucleated cell is a white blood cell, a stem cell, a stem cell progenitor cell, a gamete, a gamete progenitor cell, a hepatocyte, a muscle cell, a kidney cell, an endothelial cell, an epithelial cell, an erythroblast, a leukoblast, a chondroblast, or a pancreatic cell.

7 . The composition of claim 1 wherein the biologic is a protein, virus, nucleic acid, carbohydrate, or lipid.

8 . The composition of claim 1 wherein the membrane penetrable sugar is trehalose.

9 . The composition of claim 1 wherein the membrane impenetrable sugar is dextran.

10 . The composition of claim 1 wherein the moisture content is from about 15% to about 40%.

11 . The composition of claim 1 wherein the moisture content is from about 20% to about 25%.

12 . The composition of claim 1 wherein the biologic is a platelet, the membrane penetrable sugar is trehalose, the membrane impenetrable sugar is dextran, and the moisture content is about 15%.

13 . The composition of claim 1 wherein the biologic is a red blood cell, the membrane penetrable sugar is trehalose, the membrane impenetrable sugar is dextran, and the moisture content is about 25%.

14 . The composition of claim 1 wherein the biologic is a white blood cell, the membrane penetrable sugar is trehalose, the membrane impenetrable sugar is dextran, and the moisture content is about 50%.

15 - 34 . (canceled)

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2011
From: HO, DAVID H.; BRUTTIG, STEPHEN P.
To: HEMEMICS BIOTECHNOLOGIES, INC.
Reel/Frame 026003/0041 →