METHODS OF USING NITROXIDES IN CONJUNCTION WITH PHOTOSENSITIZERS AND SONOSENSITIZERS
The teachings herein relate to new methods of ameliorating the negative effects of a photosensitizer or sonosensitizer in a patient using a nitroxide.
1 . A method of treating a patient, comprising
administering a photosensitizer or sonosensitizer to the patient; and
administering a sufficient amount of a nitroxide to ameliorate a negative side effect resulting from said photosensitizer or sonosensitizer.
2 . The method of claim 1 , further comprising administering photodynamic therapy to the patient.
3 . The method of claim 1 wherein the photosensitizer is selected from the group consisting of porphyrins, chlorins, and phthalocyanines.
4 . The method of claim 1 , wherein the photosensitizer is porfimer sodium.
5 . The method of claim 1 , wherein the nitroxide is 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL).
6 . The method of claim 1 , wherein the negative side effect is oxidative stress.
7 . The method of claim 1 , wherein the negative side effect is photosensitivity.
8 . The method of claim 1 , wherein the negative side effect is generalized toxicity.
9 . The method of claim 1 , wherein the negative side effect is cellular apoptosis.
10 . The method of claim 1 , further comprising
applying ultrasound or sonoluminescence to a target region on the patient.