Nitric oxide amino acid ester compound, composition for increasing nitric oxide levels and method of use
There is provided novel amino acid ester compounds comprising at least one nitric oxide releasing group and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one amino acid ester compound comprising at least one nitric oxide releasing group, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. Also provided are compositions for increasing nitric oxide physiological levels in a subject, methods for increasing nitric oxide physiological levels in a subject, methods for improving a subject's muscle strength, athletic performances and/or lean body mass gain and or performance in a subject.
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein the compound of Formula (I) is:
wherein,
n=2 and
R 1 is
2. A composition for increasing nitric oxide physiological levels in a subject, which comprises a therapeutically effective amount of the compound of claim 1 in combination with a pharmaceutically acceptable carrier.
3. The composition according to claim 2 , wherein said pharmaceutically acceptable carrier is selected from the group consisting of polyethylene glycol MOL WT 330, polyethylene glycol MOL WT 300, propylene glycol monocaprylate, propylene glycol, water, sodium lauryl sulfate, salt solutions, alcohol, vegetable oils, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, surfactants, silicic acid, viscous paraffin, perfume oil, fatty acid monoglycerides and diglycerides, petroethral fatty acid esters, hydroxymethyl-cellulose and polyvinylpyrrolidon.
4. The composition according to claim 2 , wherein said pharmaceutically acceptable carrier is saliva-absorbing microcrystalline cellulose.
5. The composition according to claim 2 formulated as a liquid formulation, a liquid dosage form, an enteric-coated soft-gel capsule, a capsule, a sustained-release capsule, a tablet, a sustained release tablet, a chewable tablet, a sublingual tablet, an effervescent tablet, a pill, a powder, a granule, a gel or a suppository.
6. The composition according to claim 2 further comprising creatine.
7. The composition according to claim 2 , wherein said increase in nitric oxide levels increases vasodilatation.
8. The composition according to claim 7 , further comprising a vasodilatory compound chosen from L-arginine, norvaline, and citrulline.
9. The composition according to claim 2 further comprising 17α-hydroxy-yohimban-16α-carboxylic acid methyl ester.