IP Library › Patent Application 12806941
Patent Application
App. No. 12/806,941

Immuniostimulating polyphosphazene compounds

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
12/806,941
Abstract

Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed.

Claims (56)

1 . A polyphosphazene polymer comprising the following units:

wherein at least one R has the formula:

wherein:

wherein at least one of C, C′, or C″ includes —COOH; each of d, f, f′, f″, is from 0 to 3; each of e, e′, g, g′, g″ is from 0 to 1

and if

f=0, such that

C═—COOH

then at least one of C′, C″, Y, or Y′ is other than hydrogen; or X is other than —O—; —NH—; or —S—;

and the sum of d+e+e′+f′+f″+g′+g″ equals from 1 to 8.

2 . The polyphosphazene polymer of claim 1 wherein:

and f is 2; d, e, e′, g′ and g″ are 0, and the compound is:

3 . The polyphosphazene polymer of claim 1 wherein:

and f is 1; d, e, e′, g′ and g″ are 0, and the compound is:

4 . The polyphosphazene polymer of claim 1 wherein:

and d is 1; e, e′, f, g′, g″ are 0, and the compound is:

5 . The polyphosphazene polymer of claim 1 wherein:

and e and f are 1; d, e′, g′, and g″ are 0, and the compound is:

6 . The polyphosphazene polymer of claim 1 wherein:

and e is 1; d, e′, f, g′, and g″ are 0, and the compound is:

7 . The polyphosphazene polymer of claim 1 wherein:

and d, e, e′, g′, and g″ are 0, and the compound is:

8 . The polyphosphazene polymer of claim 1 wherein:

and d, e, e′, g, f′, and f″ are 0, and the compound is:

9 . The polyphosphazene polymer of claim 1 wherein:

and f is 2; d, e, e′, g′ and g″ are 0,

and at least a portion of the R side groups are phenoxy groups and the compound is:

wherein and a+b=2.

10 . The polyphosphazene polymer of claim 1 wherein:

and f is 2; d, e, e′, g′ and g″ are 0,

and at least a portion of the R side groups are decoxy groups and the compound is:

and wherein a+b=2.

11 . A composition for inducing an immunogenic response in a human or in an animal comprising at least one polyphosphazene polymer according to claim 1 and an antigen.

12 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the antigen is selected from the group consisting of protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof, said protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof, being derived from the group consisting of cell, bacteria, virus particle, and portions thereof.

13 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex.

14 . A composition for inducing an immunogenic response in a human or in an animal according to claim 13 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex capable of multimeric antigen presentation.

15 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the antigen is covalently conjugated to the polyphosphazene polymer.

16 . A composition for inducing an immunogenic response in a human or in an animal according to claim 11 wherein the polyphosphazene polymer is ionically cross-linked with multivalent ions to form microparticulate or microgel.

17 . A polyphosphazene polymer comprising the following units:

wherein at least one R has the following formula:

—X—Z

wherein

d is from 0 to 15.

18 . A polyphosphazene polymer according to claim 17 wherein:

and d is 5, and the compound is:

19 . A polyphosphazene polymer according to claim 17 wherein:

and d is 1, and the compound is:

20 . A polyphosphazene polymer according to claim 17 wherein:

and d is 0, and the compound is:

21 . A polyphosphazene polymer according to claim 17 wherein:

and d is 0, and the compound is:

22 . A composition for inducing an immunogenic response in a human or in an animal comprising at least one polyphosphazene polymer according to claim 17 and an antigen.

23 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the antigen is selected from the group consisting of protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof said protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, and combinations thereof, being derived from the group consisting of cell, bacteria, virus particle, and portions thereof.

24 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex.

25 . A composition for inducing an immunogenic response in a human or in an animal according to claim 24 wherein the polyphosphazene polymer and the antigen form a non-covalent water-soluble complex capable of multimeric antigen presentation.

26 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the antigen is covalently conjugated to the polyphosphazene polymer.

27 . A composition for inducing an immunogenic response in a human or in an animal according to claim 22 wherein the polyphosphazene polymer is ionically cross-linked with multivalent ions to form microparticulate or microgel.