Systems and methods for tracking and guiding high intensity focused ultrasound beams
The present disclosure provides systems and methods for tracking and guiding high intensity focused ultrasound beams (HIFU). More particularly, the disclosed systems and methods involve use of acoustic radiation force impulse (ARFI) imaging to detect the focal position of an HIFU capable transducer relative to a target area. The focal position may then be 5 compared to a desired treatment location and the orientation and focus of the transducer may be adjusted accordingly so as to reconfigure and/or refocus the HIFU beam relative to the desired treatment location. The desired treatment location may be dynamically determined using bleed detection and localization (BD&L) techniques. Thus, the desired treatment location may be determined using 3D Doppler ultrasound based techniques, wherein changes in quantitative 10 parameters extracted from the Doppler spectra, e.g., Resistance Index (RI), are used to detect and localize a bleeding site for treatment.
1. A system for facilitating administration of a High Intensity Focused Ultrasound (HIFU) beam relative to a target area, the system comprising;
a. a HIFU capable transducer;
b. a diagnostic imaging probe; and
c. a processor in communication with the HIFU capable transducer and diagnostic imaging probe, wherein the processor, HIFU capable transducer, and diagnostic imaging probe are configured to perform the processes of (i) dynamically determining a desired treatment location of the target area, wherein the step of dynamically determining includes detecting and localizing a site for treatment using 3D Doppler ultrasound based techniques, and (ii) cyclically repeating a tracking and guiding of a HIFU beam therapy before the HIFU beam therapy commences and recommences to create a dynamically self-correcting system, the tracking and guiding being applied to reorient and refocus the HIFU capable transducer, and
wherein the diagnostic imaging probe is adapted to obtain a first set of imaging data for the target area,
wherein the HIFU capable transducer is adapted to induce a radiation force relative to the target area using low power sonication,
wherein the diagnostic imaging probe is further adapted to obtain a second set of imaging data for the target area after the radiation force has been induced, and
wherein the processor is adapted to compare the first and second sets of imaging data to determine a focal position for the HIFU capable transducer relative to the target area, the processor further adapted to adjust an orientation and focus of the HIFU capable transducer such that the adjusted orientation and focus of a new focal position of the HIFU capable transducer substantially matches the desired dynamically determined treatment location of the target area.
2. The system of claim 1 , wherein the HIFU capable transducer is adapted to treat hemostasis.
3. The system of claim 1 , wherein the 3D Doppler ultrasound based techniques comprise bleed detection and localization (BD&L) techniques used to determine the desired treatment location.
4. The system of claim 1 , wherein the first and second sets of imaging data are obtained by detecting backscatter from a respective first and second tracking pulse provided by the HIFU capable transducer.
5. The system of claim 1 , wherein the processor further determines focal position by analyzing detected backscatter using cross-correlation and time-delay estimation techniques.
6. The system of claim 1 , wherein the processor further determines focal position as a region of the target area exhibiting maximum tissue displacement.
7. The system of claim 1 , wherein the HIFU capable transducer is further adapted to treat the target area with high power sonication.
8. A method for facilitating administration of a high intensity focused ultrasound (HIFU) beam relative to a target area, the method comprising:
(i) dynamically determining, via (a) a HIFU capable transducer, (b) a diagnostic imaging probe, and (c) a processor, a desired treatment location, wherein dynamically determining includes detecting and localizing a site for treatment using 3D Doppler ultrasound based techniques, and (ii) cyclically repeating a tracking and guiding of a HIFU beam therapy before the HIFU beam therapy commences and recommences to create a dynamically self-correcting method, the tracking and guiding being applied to reorient and refocus the HIFU capable transducer, and
a. probing, via the diagnostic imaging probe, the target area for a first set of imaging data;
b. inducing a radiation force relative to the target area using a low power sonication from the HIFU capable transducer;
c. probing, via the diagnostic imaging probe, the target area for a second set of imaging data;
d. comparing, via the processor, the first set of imaging data to the second set of imaging data in order to determine a focal position for the HIFU capable transducer relative to the target area; and
e. treating the target area with a high power sonication from the transducer, the method further comprising adjusting, via the processor, an orientation and focus of the HIFU capable transducer such that the adjusted orientation and focus of a new focal position of the HIFU capable transducer substantially matches the desired dynamically determined treatment location of the target area.
9. The method of claim 8 , wherein the HIFU capable transducer is used to treat hemostasis.
10. The method of claim 8 , wherein the 3D Doppler ultrasound based techniques comprise bleed detection and localization (BD&L) techniques.
11. The method of claim 8 , wherein the steps of dynamically determining, cyclically repeating, probing, inducing, probing, comparing, and treating are repeated until treatment is no longer necessary.
12. The method of claim 11 , wherein bleed detection and localization (BD&L) techniques are used to determine when treatment is no longer necessary.