Anti-cancer compounds
The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
1. A composition comprising a compound described by the following formula:
or a salt thereof, wherein X is selected from the group consisting of
wherein R is selected from the group consisting of H and ethyl, and wherein R1 is selected from the group consisting of
2. The composition of claim 1 , wherein said compound is selected from the group consisting of:
3. A pharmaceutical preparation comprising one or more of the compounds described in claim 1 and a pharmaceutically acceptable carrier.
4. A pharmaceutical preparation comprising one or more of the compounds described in claim 2 and a pharmaceutically acceptable carrier.