Process for the preparation of 6-substituted-1-(2H)-isoquinolinones
View Patent ↗The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.
1. A process for the preparation of a compound of formula (I)
or a salt thereof,
wherein
n is 1, 2, 3 or 4; and
R1 is H or a protecting group,
comprising the steps of
(A) reacting a compound of formula (II)
wherein X is halogen,
in a suitable solvent and in the presence of a base selected from a tertiary alkali metal alkoxide, alkali metal hydride or alkali metal with a compound of formula (III)
wherein
R1 is H or a protecting group and
n is 1, 2, 3 or 4,
to give a compound of formula (IV)
wherein
R1 is H or a protecting group and
n is 1, 2, 3 or 4;
and, if R1 is H, protecting the amino group to give a compound of formula (IV) wherein R1 is a amino protecting group;
(B) reacting a compound of formula (IV) with a compound of formula (V)
R 4 —CH[N(R 5 ) 2 ] 2 (V)
wherein
R 4 is —O(C 1 -C 6 )alkyl, and
R 5 is (C 1 -C 6 )alkyl,
to yield a compound of formula (VI)
wherein R1 is a protecting group and
n is 1, 2, 3 or 4; and
(C) cyclizing a compound of formula (VI) and optionally removing the protecting group in a suitable solvent and in the presence of a hydrohalic acid to give a compound of formula (I)
wherein R1 is H or a protecting group;
(D) optionally removing the protecting group from a compound of formula (I) obtained in step (C), wherein R1 is a protecting group, to give compound a formula (I) wherein R1 is H, and
(E) optionally converting a compound of formula (I) into a salt thereof.
2. The process according to claim 1 , wherein X is fluoro.
3. The process according to claim 1 , wherein the base used in step (A) is selected from a tertiary alkali metal alkoxide.
4. The process according to claim 3 , wherein the base is potassium tert-amylate or potassium tert-butoxide.
5. The process according to claim 1 , wherein R4 in reagent (V) is tert-butyloxy or ethoxy.
6. The process according to claim 1 , wherein R5 in reagent (V) is methyl.
7. The process according to claim 5 , wherein reagent (V) used in step (B) is tert-butoxy-bis-(dimethylamino)methane.
8. The process according to claim 1 , wherein the hydrohalic acid used in the cyclization reaction in step (C) is HCl.
9. The process according to claim 1 , wherein n is 3.
10. The process according to claim 1 , wherein the protecting group is an acid-labile group.
11. The process according to claim 1 , wherein the protecting group in R1 is tert-butoxycarbonyl.