IP Library › Patent Application 12830383
Patent Application
App. No. 12/830,383

DEUTERIUM-ENRICHED RISPERIDONE

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Quick Facts
Patent No.
US None
App. No.
12/830,383
Abstract

The present application describes deuterium-enriched risperidone, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.

Claims (67)

1 . (canceled)

2 . (canceled)

3 . (canceled)

4 . (canceled)

5 . (canceled)

6 . (canceled)

7 . (canceled)

8 . A deuterium-enriched compound, wherein the compound is selected from:

or a pharmaceutically acceptable salt, wherein when one of R 1 -R 27 is present, it is selected from H or D.

9 . (canceled)

10 . (canceled)

11 . (canceled)

12 . (canceled)

13 . (canceled)

14 . (canceled)

15 . (canceled)

16 . (canceled)

17 . (canceled)

18 . (canceled)

19 . (canceled)

20 . (canceled)

21 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof.

22 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-8 and R 12-27 are selected from H and D.

23 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-15 and R 25-27 are selected from H and D.

24 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-24 are selected from H and D.

25 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-24 are selected from H and D.

26 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof.

27 . A deuterium-enriched compound, wherein the compound is:

or a pharmaceutically acceptable salt thereof.

28 . A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound selected from:

or a pharmaceutically acceptable salt form thereof.

29 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt.

30 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-8 and R 12-27 are selected from H and D.

31 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-15 and R 25-27 are selected from H and D.

32 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-24 are selected from H and D.

33 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

34 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

35 . The pharmaceutical composition of claim 28 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

36 . A method for treating schizophrenia comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound selected from:

or a pharmaceutically acceptable salt form thereof.

37 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt.

38 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-8 and R 12-27 are selected from H and D.

39 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-15 and R 25-27 are selected from H and D.

40 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt thereof, wherein R 1-24 are selected from H and D.

41 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

42 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

43 . The method of claim 36 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.