LEVALBUTEROL SALT
Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.
1 - 29 . (canceled)
30 . A method of treating bronchospasm, which comprises administering to a patient a pharmaceutical composition comprising an effective amount of levalbuterol-L-tartrate using a metered dose inhaler, wherein the levalbuterol-L-tartrate is in the form of micronized crystals.
31 . The method of claim 30 , wherein the micronized crystals of levalbuterol-L-tartrate are in the form of needle-like particles.
32 . The method of claim 30 , wherein the levalbuterol-L-tartrate is a hemitartrate.
33 . The method of claim 30 , wherein the pharmaceutical composition further comprises a propellant.
34 . The method of claim 33 , wherein the propellant is 1,1,1,2-tetrafluoroethane.
35 . The method of claim 30 , wherein the pharmaceutical composition further comprises a surfactant.
36 . The method of claim 35 , wherein the surfactant is oleic acid.
37 . The method of claim 30 , wherein the pharmaceutical composition further comprises a co-solvent.
38 . The method of claim 37 , wherein the co-solvent is ethanol.
39 . The method of claim 38 , wherein the ethanol is dehydrated ethanol.
40 . The method of claim 30 , wherein the pharmaceutical composition is adapted for administration of from about 45 μg to about 90 μg levalbuterol free base per actuation.