Granted Patent
B2
US 8,562,997 · App. 12/837,409 · Granted Oct 22, 2013
Methods of treating acute myeloid leukemia by blocking CD47
Inventors:
Siddhartha Jaiswal (San Francisco, CA); Irving L. Weissman (Stanford, CA); Ravindra Majeti (Stanford, CA); Mark P. Chao (Mountain View, CA)
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Abstract
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
Claims (3)
1. A method of treating a human subject having acute myeloid leukemia (AML), the method comprising:
administering to the human subject an antibody that prevents the binding of CD47 with SIPRα, at a dose that achieves a depletion in circulating AML stem cells (AMLSC).
2. The method of claim 1 , wherein the depletion achieves a reduction in circulating AMLSC by 75% or more.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Dec 6, 2010
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 025444/0973 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 29, 2010
From: JAISWAL, SIDDHARTHA; WEISSMAN, IRVING L.; MAJETI, RAVINDRA; CHAO, MARK P.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 025063/0688 →
Continuity (4)
Continuation In Part
PCTUS2009000319
· Jan 15, 2009
Provisional Application
61011324
· Jan 15, 2008
Provisional Application
61189786
· Aug 22, 2008