CANCER TREATMENT USING VIRUSES, FLUOROPYRIMIDINES AND CAMPTOTHECINS
Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.
1 . A method of treating a mammalian subject having a neoplasm, comprising administering to the subject a virus, a fluoropyrimidine, and a camptothecin compound in one or more cycles in a combined amount effective to treat the subject;
wherein the virus is selected from the group consisting of a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.
3 . The method of claim 1 , wherein the virus is administered intravenously.
4 . The method of claim 1 wherein the fluoropyrimidine compound is 5-fluorouracil.
5 . The method of claim 4 , further comprising administering to the subject leucovorin.
6 . The method of claim 4 , wherein the 5-fluorouracil is administered by continuous infusion over a period of at least 22 hours per dose.
7 . The method of claim 1 wherein the camptothecin compound is selected from the group consisting of topotecan, 9-aminocamptothecin, exatecan, karenitecin, rubitecan, lurtotecan, and a homocamptothecin.
8 . The method of claim 1 , wherein the camptothecin compound is irinotecan.
9 . The method of claim 1 , wherein the fluoropyrimidine compound is 5-fluorouracil, and the camptothecin compound is irinotecan.
10 . The method of claim 1 , wherein the virus, the fluoropyrimidine compound, and the camptothecin compound are administered in two or more cycles.
11 . The method of claim 1 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one month before administration of the virus.
12 . The method of claim 11 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one week before administration of the virus.
13 . The method of claim 1 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one month after administration of the virus.
14 . The method of claim 13 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one week after administration of the virus.
15 . The method of claim 1 , wherein the neoplasm is a colon carcinoma.