Fused heterocyclic compounds as ion channel modulators

1. A compound of Formula III:

wherein:

R 1 is aryl or heteroaryl;

wherein said aryl is substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, —NO 2 , CN, —SF 5 , —Si(CH 3 ) 3 —O—CF 3 , —O—R 20 , —S—R 20 , —C(O)—R 20 , C(O)OH, —N(R 20 )(R 22 ), —C(O)—N(R 20 )(R 22 ), —N(R 20 )—C(O)—R 22 , —N(R 20 )—S(═O) 2 —R 26 , —S(═O) 2 —R 20 , —S(═O) 2 —N(R 20 )(R 22 ), C 1-3 alkoxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, cycloalkyl, heteroaryl, and heterocyclyl;

wherein said alkoxy, alkyl, alkenyl, alkynyl, heteroaryl, cycloalkyl, or heterocyclyl is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, —NO 2 , —O—CF 3 , —O—CF 2 , phenyl, heterocyclyl, heteroaryl, cycloalkyl, —N(R 20 )(R 22 ), —C(O)—R 20 , C(O)—R 20 , —C(O)—N(R 20 )(R 22 ), —CN, and —O—R 20 ;

wherein said heteroaryl is substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, —NO 2 , CN, —SF S , —Si(CH 3 ) 3 —O—CF 3 , —S—R 20 , —S—R 20 , C(O)OH, —N(R 20 )(R 22 ), —C(O)—N(R 20 )(R 22 ), —N(R 20 )—C(O)—R 22 , —N(R 20 )—S(═O) 2 —R 26 , —S(═O) 2 —R 20 , —S(═O) 2 —N(R 20 )(R 22 ), C 1-3 alkoxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, cycloalkyl, heteroaryl, and heterocyclyl;

wherein said alkoxy, alkyl, alkenyl, alkynyl, heteroaryl, cycloalkyl, or heterocyclyl is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, —NO 2 , —O—CF 3 , —O—CF 2 , phenyl, heterocyclyl, heteroaryl, cycloalkyl, —N(R 20 )(R 22 ), —C(O)—R 20 , —C(O)—O—R 20 , —C(O)—N(R 20 )(R 22 ), —CN, and —O—R 20 ;

R 2 is independently selected from the group consisting of hydrogen, optionally substituted alkyl, amino, optionally substituted alkoxy, —CF 3 , —O—CF 3 , —CN, and —N(R 20 )C(O)—R 22 ;

R 3 is independently selected from the group consisting of hydrogen, alkyl, —CF 3 , -halo, and —O—R 24 ;

R 4 is independently selected from the group consisting of hydrogen, hydroxyl, halo, C 1-4 alkyl, C 1-3 alkoxy, —R 25 —N(R 20 )(R 22 ), —R 25 —O—R 20 , —R 25 —C(O)—O—R 20 , —R 25 —C(O)—N(R 20 )(R 22 ), —R 25 —C(O)—O—N(R 20 )(R 22 ), —R 25 —N(R 20 )—C(O)—R 22 , and —R 25 —O—C(O)—N(R 20 )(R 22 );

wherein said alkyl is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl and halo;

Q is a covalent bond or C 2-4 alkynylene;

R a is hydrogen, C 1-15 alkyl, C 1-4 alkoxy, —C(O)—O—R 26 , —C(O)—N(R 26 )(R 28 )—S(═O) 2 —R 20 , cycloalkyl, aryl, heteroaryl, or heterocyclyl;

wherein said alkyl is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, —NO 2 , —O—CF 3 , —O—CHF 2 , cycloalkyl, —CN, and C 1-4 alkoxy;

wherein said alkoxy, cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, —NO 2 , —O—CF 3 , —O—CHF 2 , phenyl, heterocyclyl, heteroaryl, cycloalkyl, —N(R 20 )(R 22 ), —C(O)—R 20 , —C(O)—O—R 20 , —C(O)—N(R 20 )(R 22 ), —CN, and —O—R 20 ; or

R a is —Y—Z—R 25 —R 23 —R 20 , wherein Y is a covalent bond or selected from C 1-3 alkylene optionally substituted with one or two C 1-3 alkyl or fluoro groups;

Z is C 2-4 alkynylene, —O—, —S—, —NR″, —NR 5′ —C(O)—, —NR″—C(O)—NR 5′ —, or —C(O)—NR 3 —, wherein each R″ and R 5′ is independently hydrogen or C 1-6 lower alkyl; and

further wherein said alkyl is optionally substituted with one, two, or three substituents independently selected from hydroxyl, halo, —NO 2 , —O—CF 3 , —O—CF 2 , phenyl, heterocyclyl, heteroaryl, cycloalkyl, —N(R 20 )(R 22 ), —C(O)—R 20 , —C(O)—O—R 20 , —C(O)—N(R 20 )(R 22 ), —CN, and —O—R 20 ;

R 20 and R 22 are in each instance independently selected from the group consisting of hydrogen, C 1-15 alkyl, C 2-15 alkenyl, C 2-15 alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;

wherein said alkyl, alkenyl, alkynyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, alkyl, mono- or dialkylamino, alkyl or aryl or heteroaryl amide, —NO 2 , —SO 2 R 26 , —CN, C 1-3 alkoxy, —CF 3 , —OCF 3 , aryl, cycloalkyl, and heteroaryl; or

when R 20 and R 22 are attached to a common nitrogen atom, R 20 and R 22 may join to form a heterocyclic ring optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, alkyl, mono- or dialkylamino, alkyl or aryl or heteroaryl amide, —NO 2 , —SO 2 R 26 , —CN, C 1-3 alkoxy, —CF 3 , —OCF 3 , aryl, and cycloalkyl;

R 23 is a covalent bond or is selected from the group consisting of cycloalkylene, heterocyclylene, arylene, and heteroarylene;

wherein said cycloalkylene, heterocyclylene, arylene, or heteroarylene is optionally substituted with one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, alkyl, mono- or dialkylamino, alkyl or aryl or heteroaryl amide, —NO 2 , —SO 2 R 26 , —CN, C 1-3 alkoxy, —CF 3 , —OCF 3 , aryl, cycloalkyl, and heteroaryl;

R 24 is in each instance independently selected from alkyl or aryl either of which may be optionally substituted with one, two, or three groups independently selected from the group consisting of hydroxyl, —OCF 3 , halo, C 1 -C 3 alkoxy, —O—R 20 , or alkyl optionally substituted with halo, —NO 2 , —CF 3 , —N(R 20 )(R 22 ), —C(O)—R 20 , C(O)—O—R 20 , —C(O)—N(R 20 )(R 22 ), —CN, and —O—R 20 ;

R 25 is in each instance independently a covalent bond or selected from C 1-3 alkylene optionally substituted with one or two C 1-3 alkyl groups; and

R 26 and R 28 are in each instance independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl, wherein said alkyl, and cycloalkyl may be further substituted with from one, two, or three substituents independently selected from the group consisting of hydroxyl, halo, C 1-4 alkoxy, —CF 3 , and —OCF 3 ;

or a pharmaceutically acceptable salt thereof,

with the proviso that

a. when R a is —Y—Z—R 25 —R 23 —R 20 , Y is not a covalent bond and Z is —O—, —S—, —SO 2 —, —C(O)—NR 3 —, —NR 5′ —C(O)—, or NR″—, then R 25 cannot be a bond;

b. when R a is —Y—Z—R 25 —R 23 —R 20 , Y is covalent bond and Z is —O—, —S—, or NR″—, then R 25 is a covalent bond and R 23 is not cycloalkylene;

c. when Z is —NR 5′ —C(O)—, then Y is not a covalent bond;

d. R 23 and R 25 cannot both be covalent bonds;

f. when R 2 is substituted alkyl, then R a is not alkyl, cycloalkyl, or heterocyclyl; and

g. when Q is a covalent bond, and R 1 is phenyl, then R a is not C 1-3 unsubstituted alkyl.

2. The compound of claim 1 , wherein Q is C 2-4 alkynylene.

3. The compound of claim 2 , wherein the compound is selected from the group consisting of:

3-(trifluoromethyl)-6-{[4-(trifluoromethyl)phenyl]ethynyl}[1,2,4]triazolo[4,3-a]pyridine;

2,2-difluoro-2-(6-{[4-(trifluoromethyl)phenyl]ethynyl}[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethanol;

3-(1,1-difluoro-2-methoxyethyl)-6-{[4-(trifluoromethyl)phenyl]ethynyl}[1,2,4]triazolo[4,3-a]pyridine;

3-phenoxy-6-{[4-(trifluoromethyl)phenyl]ethynyl}[1,2,4]triazolo[4,3-a]pyridine;

3-(1,1-difluoro-2-methoxyethyl)-6-{[4-(trifluoromethoxy)phenyl]ethynyl}[1,2,4]triazolo[4,3-a]pyridine; and

3-(1,1-difluoro-2-methoxyethyl)-6-[(4-fluorophenyl)ethynyl][1,2,4]triazolo[4,3-a]pyridine.

4. The compound of claim 1 , wherein R 1 is heteroaryl.

5. The compound of claim 4 , wherein the compound is selected from the group consisting of:

6-(6-cyclopropylpyridin-3-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(2-cyclopropylpyrimidin-5-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

3-(trifluoromethyl)-6-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[4,3-a]pyridine;

6-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

3-(trifluoromethyl)-6-[6-(trifluoromethyl)pyridazin-3-yl][1,2,4]triazolo[4,3-a]pyridine;

3-(trifluoromethyl)-6-[2-(trifluoromethyl)pyrimidin-5-yl][1,2,4]triazolo[4,3-a]pyridine;

3-(1,1-difluoro-2-methoxyethyl)-6-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl][1,2,4]triazolo[4,3-a]pyridine;

6-[6-(cyclopropyloxy)pyridin-3-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[6-(2,2,2-trifluoroethoxy)pyridazin-3-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

3-[(cyclopropylmethoxy)(difluoro)methyl]-6-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(5-phenyl-1,2-oxazol-3-yl)methoxy]methyl}-6-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[4,3-a]pyridine; and

3-{difluoro[(5-phenyl-1,2-oxazol-3-yl)methoxy]methyl}-6-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl][1,2,4]triazolo[4,3-a]pyridine.

6. The compound of claim 1 , wherein R a is aryl.

7. The compound of claim 6 , wherein the compound is selected from the group consisting of:

3-phenyl-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-phenyl-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-8-amine;

3,6-bis[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

4-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzenesulfonamide;

N-(4-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl)methanesulfonamide;

4-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzamide;

diethyl 3,3′-[1,2,4]triazolo[4,3-a]pyridine-3,6-diyldibenzoate;

ethyl 4-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzoate;

ethyl 3-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzoate;

N-(2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl)methanesulfonamide;

N-methyl-3-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzamide; and

N-[5-(trifluoromethoxy)-2-{3-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-6-yl}phenyl]acetamide.

8. The compound of claim 1 , wherein R a is —Y—Z—R 25 —R 23 —R 20 .

9. The compound of claim 8 , wherein Y is —CF 2 — and Z is O.

10. The compound of claim 9 , wherein the compound is selected from the group consisting of:

3-[difluoro(methoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(2-methoxyethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(3-methyloxetan-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(benzyloxy)(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(pyridin-4-ylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

2-(difluoro {6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)ethanol;

1-(difluoro {6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)propan-2-ol;

3-{difluoro[(5-methyl-1,2-oxazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(pyridin-3-ylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(5-cyclopropyl-1,2,4-oxadiazol-3-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[5-(2-methylpropyl)-1,2,4-oxadiazol-3-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[5-(propan-2-yl)-1,2,4-oxadiazol-3-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(pyridin-2-ylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

4-[(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]quinoline;

3-[(cyclopropylmethoxy)(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(pyridazin-3-ylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[1-(4-fluorophenyl)ethoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(1-methyl-5-phenyl-1H-pyrazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(2,2-difluoro-1,3-benzodioxol-5-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(2,5-dimethyl-1,3-oxazol-4-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[1-(pyridin-2-yl)ethoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[1-(4-chlorophenyl)ethoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(pyrimidin-2-ylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[1-(2,4-dichlorophenyl)ethoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

1-[(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]cyclobutanol;

tert-butyl (2S)-2-[(difluoro {6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl]methoxy)methyl}pyrrolidine-1-carboxylate;

3-{[(5-cyclobutyl-1,2,4-oxadiazol-3-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(difluoro {6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]benzonitrile;

3-(difluoro {3-[(2-methoxyphenyl)sulfanyl]-2-methylpropoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro(1-{3-[4-(trifluoromethyl)phenyl]-1,2-oxazol-5-yl}ethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

5-[(difluoro {6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]quinoline;

3-[1-(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)ethyl]quinoline;

3-{[2-(2,6-dimethylphenoxy)ethoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(1-phenyl-1H-pyrazol-4-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[difluoro({2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]methoxy)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

4-[(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]-2-methylquinoline;

4-[(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]-2-(trifluoromethyl)quinoline;

6-[(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]quinoxaline;

3-[(but-2-yn-1-yloxy)(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(2,2-difluorocyclopropyl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(3-phenylprop-2-yn-1-yl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(1-methyl-1H-benzimidazol-2-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(5-phenyl-1,2-oxazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(2-phenyl-1,3-oxazol-4-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(1-methyl-1H-pyrazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[{[1-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-yl]methoxy}(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(3,3-diphenylpropoxy)(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro {[3-(pyrimidin-2-yl)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[3-(pyridin-3-yl)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(1-methyl-1H-indazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro {[2-(1H-1,2,4-triazol-1-yl)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro {[2-(2-methyl-1H-imidazol-1-yl)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro {[2-phenyl-5-(trifluoromethyl)-1,3-oxazol-4-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[6-(1H-pyrazol-1-yl)pyridin-3-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

6-cyclopropyl-2′-[(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methoxy)methyl]-3,4′-bipyridine;

3-[{[3-(4-cyclopropyl-1H-imidazol-1-yl)benzyl]oxy}(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[5-(4-fluorophenyl)-1,2-oxazol-3-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{[2-(piperidin-1-yl)pyridin-4-yl]methoxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[2-(2,6-difluorophenyl)ethoxy](difluoro)methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{difluoro[(5-phenyl-1,2,4-oxadiazol-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[{[2-(6-cyclopropylpyridin-3-yl)benzyl]oxy}(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[{[5-(2-chlorophenyl)-1,2-oxazol-3-yl]methoxy}(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

GS-466738 3-(difluoro {[2-(pyridin-3-yl)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine; and

GS-466739 3-(difluoro {[2-(1H-pyrazol-1-yl)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine.

11. The compound of claim 8 , wherein Y is —CF 2 — and Z is O.

12. The compound of claim 11 , wherein the compound is selected from the group consisting of:

3-(1,1-difluoro-2-methoxyethyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

2,2-difluoro-2-[6-(4-phenoxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethanol;

3-(1,1-difluoro-2-methoxyethyl)-6-(4-phenoxyphenyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(4-chlorophenoxy)phenyl]-3-(1,1-difluoro-2-methoxyethyl)[1,2,4]triazolo[4,3-a]pyridine;

3-(1,1-difluoro-2-methoxyethyl)-6-[4-(4-fluorophenoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[1,1-difluoro-2-(pyridin-3-ylmethoxy)ethyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

2-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethoxy)-N,N-dimethylethanamine;

(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethoxy)acetonitrile;

1,1-difluoro-1-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}propan-2-ol;

1-cyclopropyl-2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethanol;

ethyl (2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethoxy)acetate;

3-[1,1-difluoro-2-(pyridin-2-ylmethoxy)ethyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

1,1-difluoro-2-methyl-1-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}propan-2-ol;

3-(1,1-difluoro-2-methoxyethyl)-6-[3-methyl-4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{2-[(3,4-difluorobenzyl)oxy]-1,1-difluoroethyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(difluoro{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methyl)pentan-3-ol;

3-(1,1-difluoro-2-methoxyethyl)-6-[2-methyl-4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

1-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethoxy)-2-methylpropan-2-ol;

3-(1,1-difluoro-2-methoxyethyl)-6-[3-fluoro-4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(1,1-difluoro-2-methoxyethyl)-6-(3,5-difluoro-4-phenoxyphenyl)[1,2,4]triazolo[4,3-a]pyridine;

3-{2-[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methoxy}-1,1-difluoroethyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

1-(2-chlorophenoxy)-3-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethoxy)propan-2-ol; and

1-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethoxy)-3-(2,5-dimethylphenoxy)propan-2-ol.

13. The compound of claim 1 , wherein R a is C 1-15 alkyl optionally substituted with halo, hydroxyl, cyclopropyl, methoxy, or amino.

14. The compound of claim 13 , wherein the compound is selected from the group consisting of:

7-methyl-6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine;

6-(3-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine;

3-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-a]pyridine;

6-(2,4-dichlorophenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(difluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(3-phenoxyphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-chloro-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(4-chloro-3-fluorophenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

7-methyl-6-[3-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(4-tert-butylphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

3-(trifluoromethyl)-6-[4-(trimethylsilyl)phenyl][1,2,4]triazolo[4,3-a]pyridine;

6-(4-methoxyphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(2,2,2-trifluoroethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

methyl 4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzoate;

2-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}propan-2-ol;

4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzonitrile;

6-[2-(1H-tetrazol-5-yl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(biphenyl-4-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(1-methyl-1H-indazol-5-yl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(1H-1,2,4-triazol-1-yl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(4-fluorophenoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(4-chlorophenoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

2-methyl-2-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}propanenitrile;

6-[3-methyl-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(propan-2-ylsulfonyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[3-(morpholin-4-ylmethyl)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(4-ethoxyphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-(4-tert-butoxyphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-{3-[(4-methylpiperazin-1-yl)methyl]-4-(trifluoromethoxy)phenyl}-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

N,N-dimethyl-1-{2-(trifluoromethoxy)-5-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}methanamine;

2-({2-(trifluoromethoxy)-5-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzyl}amino)ethanol;

6-(4-cyclopropylphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(pyrazin-2-yloxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(pyridin-3-yloxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(cyclopropyloxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

8-methyl-6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

7-methoxy-6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[2-methoxy-4-(trifluoromethyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

3-(trifluoromethyl)-6-(3,4,5-trimethoxyphenyl)[1,2,4]triazolo[4,3-a]pyridine;

8-(trifluoromethoxy)-5-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]quinoline;

6-(3,5-difluoro-4-phenoxyphenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(4-fluoro-2-nitrophenoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(2-fluorophenoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(pyridin-4-yloxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

N-phenyl-4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]aniline;

N-(2,2,2-trifluoroethyl)-4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]aniline;

6-[4-(phenylsulfanyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]-N-(2,2,2-trifluoro-1-phenylethyl)aniline;

6-[2-bromo-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[2-(2-methoxypyrimidin-5-yl)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[2-(pyridin-3-yl)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

2-(trifluoromethoxy)-5-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]aniline;

1-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}cyclopentanecarbonitrile;

6-[2-fluoro-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[3-fluoro-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(cyclopropylmethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[2-methoxy-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[3-(1,3,4-oxadiazol-2-yl)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

1-(4-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl)ethanone;

5-(trifluoromethoxy)-8-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]quinoline;

6-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[3-chloro-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

(2E)-3-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}but-2-enenitrile;

N-methyl-2-(trifluoromethoxy)-5-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzamide;

6-[2-(2-methoxyethoxy)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

{5-(trifluoromethoxy)-2-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenoxy}acetonitrile;

6-[3-(3-methyl-1,2,4-oxadiazol-5-yl)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(trifluoromethoxy)-3-(trifluoromethyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

1-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}cyclopropanecarbonitrile;

6-[2,4-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

5-methyl-6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[4-(2-methoxypropan-2-yl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[2-ethoxy-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-[2-(propan-2-yloxy)-4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

4-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}tetrahydro-2H-pyran-4-carbonitrile;

6-{4-[difluoro(pyridin-3-yl)methoxy]phenyl}-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

6-{4-[difluoro(phenyl)methoxy]phenyl}-3-(trifluoromethyl) [1,2,4]triazolo[4,3-a]pyridine;

5-chloro-2-({4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}amino)benzonitrile;

5-(methoxymethyl)-6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine;

N-methyl-N-phenyl-4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]aniline;

({6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-5-yl}methoxy)acetonitrile;

4-(difluoro{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenoxy}methyl)benzonitrile;

4-chloro-N-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}aniline;

4-fluoro-N-{4-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl}aniline;

6-[4-(pentafluoro-lambda-6-sulfanyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine; and

6-(2-chloro-4-nitrophenyl)-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine.

15. The compound of claim 1 , wherein R 1 is aryl substituted with halo, hydroxyl, methoxy, ethoxy, —OCF 3 , or amino.

16. The compound of claim 15 , wherein the compound is selected from the group consisting of:

{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}acetic acid;

3-(difluoromethyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(propan-2-yl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

methyl 6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine-3-carboxylate;

N-methyl-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine-3-carboxamide;

3-methyl-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-8-amine;

3-methyl-6-[2-methyl-4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-8-amine;

N-{3-methyl-6-[2-methyl-4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}acetamide;

3-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

N-{3-methyl-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propanamide;

N-({6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methyl)methanesulfonamide;

3-(difluoromethyl)-8-methoxy-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(benzyloxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(cyclopropylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(2,2,2-trifluoroethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}methanol;

3-phenoxy-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

2,2,2-trifluoro-1-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethanol;

3-(2-chloro-1,1-difluoroethyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

N,N-dimethyl-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-amine;

3-(phenylsulfanyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(cyclopropylethynyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

2-methyl-4-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}but-3-yn-2-ol;

N-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)methanesulfonamide;

N-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)pyridine-2-carboxamide;

3-methoxy-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-(2,2,2-trifluoroethoxy)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

6-[4-(trifluoromethoxy)phenyl]-3-({[4-(trifluoromethyl)benzyl]oxy}methyl)[1,2,4]triazolo[4,3-a]pyridine;

3-{[(4-fluorobenzyl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(2-fluorobenzyl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

6-[4-(trifluoromethoxy)phenyl]-3-({[2-(trifluoromethyl)benzyl]oxy}methyl)[1,2,4]triazolo[4,3-a]pyridine;

3-{[(2,4-difluorobenzyl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(4-chlorobenzyl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-({[4-(trifluoromethoxy)benzyl]oxy}methyl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

N-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)benzamide;

3-[(pyridin-2-ylmethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[(1-phenylethoxy)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo-[4,3-a]pyridine;

3-{1-[difluoro(pyridin-3-yl)methoxy]ethyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo-[4,3-a]pyridine;

3-{[(2,4-dichlorobenzyl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(2,4-dimethylbenzyl)oxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[(5-methylpyridin-2-yl)methoxy]methyl}-6-[ 4 4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-[1-(pyridin-2-ylmethoxy)ethyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

3-{[difluoro(pyridin-3-yl)methoxy]methyl}-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine;

6-[4-(trifluoromethoxy)phenyl]-3-[3-(trifluoromethyl)phenoxy][1,2,4]triazolo[4,3-a]pyridine;

3-(4,4-difluoropiperidin-1-yl)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo-[4,3-a]pyridine;

1-(2,2-difluoro-2-{6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)-3-phenylurea;

6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine-3-carboxamide;

3-(2-methylphenoxy)-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine; and

3-[chloro(difluoro)methyl]-6-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[4,3-a]pyridine.

17. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

18. 6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine, represented by the structure

or a pharmaceutically acceptable salt thereof.