Process for the manufacture of pharmaceutically active compounds

1. A process for the manufacture of the compound of formula (1),

comprising the steps of reacting the compound of formula (5),

with 4-chlorophenylboronic acid in the presence of a palladium Catalyst to produce the compound of formula (6),

 and

cleaving the 2,6-dichlorobenzamide group in said compound of formula (6) to produce the compound of formula (1).

2. The process according to claim 1 , wherein the compound of formula (5) is obtained by:

reacting the compound of formula (2),

with oxalylchloride to produce the corresponding acid chloride;

reacting said acid chloride with 5-bromo-7-azaindole in the presence of aluminium trichloride to produce the compound of formula (4),

 and

reacting said compound of formula (4) with 2,6-dichlorobenzoylchloride to produce the compound of formula (5).

3. The process according to claim 1 , wherein:

(A) said compound of formula (5) is obtained by:

reacting the compound of formula (2)

with oxalylchloride in the presence of methylenechloride and N,N-Dimethylformamide to produce the corresponding acid chloride;

reacting said acid chloride with 5-bromo-7-azaindole in the presence of aluminium trichloride to produce the compound of formula (4)

 and

reacting said compound of formula (4) with dichlorobenzoylchloride in the presence of dimethylaminopyridine and n-tripropylamine to produce the compound of formula (5)

 and

(B) said cleavage of the 2,6-dichlorobenzamide group in said compound of formula (6) is accomplished by reacting said compound with ammonia in methanol or ethanol solution diluted with a polar aprotic solvent.