Microjet drug delivery system
The present invention relates to a novel type of a needle-free drug delivery system in which strong energy such as a laser beam is focused inside liquid contained in a sealed pressure chamber to cause bubble growth and the volume expansion in the sealed pressure chamber due to the bubble growth so as to elongate an elastic membrane, so that an instantaneous pressure is applied to a drug solution contained in a drug microchamber adjacent to the elastic membrane to allow the drug solution to be injected in the form of a liquid microjet, thereby enabling the drug solution to rapidly and accurately penetrate into the bodily tissues of the patient.
1. A microjet drug delivery system, comprising:
a pressure chamber having a predetermined sealed accommodating space formed therein and storing a pressure-generating liquid in the sealed accommodating space;
a drug microchamber disposed in proximity to and separately from the pressure chamber and configured to accommodate a drug solution in a predetermined accommodating space formed therein;
an energy-focusing device disposed separately and completely outside from the sealed accommodating space and configured to focus energy to the pressure-generating liquid stored in the pressure chamber to cause bubble growth due to vaporization of the pressure-generating liquid;
an elastic membrane disposed between the pressure chamber and the drug microchamber; and
a micronozzle connected to one side of the drug microchamber so as to be formed as a passageway through which the drug solution stored in the drug microchamber is injected to the outside in the form of a microjet.
2. The microjet drug delivery system according to claim 1 , wherein the energy-focusing device is a laser generator that generates a laser beam and focusably irradiates the generated laser beam onto the pressure-generating liquid stored in the pressure chamber.
3. The microjet drug delivery system according to claim 1 , wherein the energy-focusing device is an electrode that allows electrical energy to pass therethrough.
4. The microjet drug delivery system according to claim 1 , wherein the pressure-generating liquid stored in the pressure chamber is any one selected from among water, alcohol and high-molecular compound of a gel or sol state.
5. The microjet drug delivery system according to claim 4 , wherein the pressure-generating liquid comprises an electrolytic material dissolved therein.
6. The microjet drug delivery system according to claim 1 , wherein the drug microchamber is connected to a drug reservoir having a drug solution contained therein so that the drug solution stored in the drug microchamber can be injected to the outside in the form of a microjet and then can be supplied with the drug solution from the drug reservoir.
7. The microjet drug delivery system according to claim 1 , wherein the elastic membrane is made of a nitrile butadiene rubber (NBR).
8. The microjet drug delivery system according to claim 1 , wherein the micronozzle comprises an exit having a coating layer formed on the inner peripheral surface thereof.
9. The microjet drug delivery system according to claim 2 , wherein the pressure chamber is formed of a transparent material at one side surface thereof.
10. The microjet drug delivery system according to claim 9 , wherein the one side surface of the pressure chamber formed of the transparent material is processed in the form of a lens.
11. An apparatus for injecting liquid in the form of a microjet, the apparatus comprising:
a pressure chamber having a predetermined sealed accommodating space formed therein and storing a pressure-generating liquid in the sealed accommodating space;
a microchamber disposed in proximity to and separately from the pressure chamber and configured to accommodate a to-be-injected drug solution in a predetermined accommodating space formed therein, the drug solution being injected in the form of a microjet;
an elastic membrane disposed between the pressure chamber and the microchamber and configured to partition the pressure chamber and the microchamber from each other;
a laser device comprising a laser generator for generating a laser beam and configured to focusably irradiate the generated laser beam onto the pressure-generating liquid stored in the pressure chamber, the laser device being disposed separately and completely outside from the sealed accommodating space of the pressure chamber; and
a micronozzle formed as a passageway through which the to-be-injected drug solution stored in the drug microchamber is injected to the outside in the form of a microjet.